Results 41 to 50 of about 7,998,250 (290)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Family Culture and Firm Performance: The Moderating Roles of Two Distinct Strategic Orientations in Nigerian Family Businesses:Family Culture and Firm Performance [PDF]

, 2015
Family businesses have been critical to the economic landscape of many developed countries for centuries and remain so till today. The role of family involvement in these businesses remains an important line of enquiry in family business research ...
Wale-Oshinowo, Bamidele
core   +2 more sources

VALUES AND GOALS IN THE MANAGEMENT OF ROMANIAN FAMILY BUSINESSES

Annals of the University of Oradea: Economic Science
The paper discusses the issues related to the connection between the family values and the family firm goals in Romanian family businesses. The values of the family are the foundation of the values of the family firm and they represent the core of the ...
Răzvan Cristian MUSCĂ, Maria Madela ABRUDAN, Nicolae Aurelian BIBU   +2 more
doaj   +1 more source

Family firm versus non-family firm : the role of resource orchestration in fast-growing high-tech SMEs

, 2022
Purpose: This paper strives to understand the role of resource orchestration (RO) in the rapid growth of high-tech small and medium-sized enterprises (SMEs).
Andersén, Jim, Ljungkvist, Torbjörn, Boers, Börje,, Torbjörn Ljungkvist, Börje Boers, Jim Andersén, Boers, Börje, Ljungkvist, Torbjörn,, Andersén, Jim,   +8 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The distinctiveness of family firm intangibles: An empirical study

, 2012
This paper estimates the effects of four intangible resources —family organizational culture, family firm reputation, human capital and networks— and their combinations on firm performance in a private-family firm setting.
Steijvers, Tensie, Lybaert, Nadine, Voordeckers, Wim, Huybrechts, Jolien, Lambrechts, Frank   +4 more
core   +1 more source

PILIHAN BAHASA MASYARAKAT SAMIN DALAM RANAH KELUARGA

Humaniora, 2012
The language choice of Samin society in Blora is an interesting phenomenon to study by the perspective of sociolinguistic since it is related not only to language aspect, but also to socio-cultural aspect.
Hari Bakti Mardikantoro
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source