Results 81 to 90 of about 1,613,013 (264)

Family functioning of elderly with depressive symptoms

Revista da Escola de Enfermagem da USP, 2014
Objective: To classify families of elderly with depressive symptoms regarding their functioning and to ascertain the presence of an association between these symptoms, family functioning and the characteristics of the elderly.
Rosely Almeida Souza, Gislaine Desani da Costa, Cintia Hitomi Yamashita, Fernanda Amendola, Jaqueline Correa Gaspar, Márcia Regina Martins Alvarenga, Odival Faccenda, Maria Amélia de Campos Oliveira   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Family Functioning in Adolescents with Perinatal HIV Infection

Journal of the International Association of Providers of AIDS Care, 2018
This study aimed to assess family functioning in adolescents with perinatal HIV infection receiving antiretroviral therapy compared with healthy controls. Correlations between self-reported and caregiver-reported family functions were also evaluated.
Orawan Louthrenoo MD, Linda Aurpibul MD, Peninnah Oberdorfer MD, PhD, Virat Sirisanthana MD   +3 more
doaj   +1 more source

Adolescent attachment, family functioning and depressive symptoms

South African Journal of Psychiatry, 2015
Background. Adolescence represents a challenging transitional period where changes in biological, emotional, cognitive and social domains can increase the risk of developing internalised problems including subthreshold depression.
Nishola Rawatlal, Wendy Kliewer, Basil J Pillay   +2 more
doaj   +1 more source

The Role of Acculturation Differences and Acculturation Conflict in Latino Family Mental Health [PDF]

, 2018
In order to help address the mental health disparities that exist for Latino families in the U.S., the current study sought to examine the acculturation–mental health link within the context of Latino families and to identify potential mechanisms for ...
Gerdes, Alyson C., Kapke, Theresa Lauer, Lawton, Kathryn E.   +2 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Family functioning and moral development of students [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2020
This paper presents the results of an empirical study into the relationship between family functioning and the level of moral development in senior students (adolescents), designed and conducted to take into consideration the more complete definition of ...
Jerković Ljiljana S., Ilić Mile Đ.
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source