Results 101 to 110 of about 4,643,088 (305)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

a^*‐families of analytic functions

International Journal of Mathematics and Mathematical Sciences, 1984
Using convolutions, a new family of analytic functions is introduced. This family, called a*‐family, serves in certain situations to unify the study of many previously well known classes of analytic functions like multivalent convex, starlike, close‐to‐convex or prestarlike functions, functions starlike with respect to symmetric points and other such ...
G. P. Kapoor, A. K. Mishra
openaire   +3 more sources

Relational functioning in the family systems of children with social competency disorders [PDF]

, 2008
textDespite a remarkable need and demand for services, little is known about the family relationships of children with social competency disorders (SCD), defined in this study as children with Asperger’s Disorder and nonverbal learning disabilities (NVLD)
Kruschwitz, Moana Gayle, 1973-
core  

Cumulative risk and internalizing and externalizing problems in early childhood: Compensatory and buffering roles of family functioning and family regularity

, 2022
In this preregistered study, we studied the extent to which family functioning and family regularity compensated for (compensatory model of resilience, Garmezy et al., Child Development 55:97–111, 1984) and buffered against (risk-protective factor model ...
Hogye, Sari, Jansen, Pauline, Hogye, Sari; id_orcid, Lucassen, Nicole, Schuurmans, Isabel; id_orcid, Keizer, Renske; id_orcid, Lucassen, Nicole; id_orcid, Schuurmans, Isabel, Keizer, Renske   +8 more
core   +1 more source

Family functioning and moral development of students [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2020
This paper presents the results of an empirical study into the relationship between family functioning and the level of moral development in senior students (adolescents), designed and conducted to take into consideration the more complete definition of ...
Jerković Ljiljana S., Ilić Mile Đ.
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Entrustable professional activity utilization: A CERA study of family medicine residency program directors [PDF]

, 2019
BACKGROUND AND OBJECTIVES: Entrustable professional activities (EPAs) is a novel assessment framework in competency-based medical education. While there are published pilot reports about utilization and validation of EPAs within undergraduate medical ...
Jarrett, Jennie B., Antoun, Jumana M., Hasnain, Memoona   +2 more
core   +1 more source

Family functioning of elderly with depressive symptoms

Revista da Escola de Enfermagem da USP, 2014
Objective: To classify families of elderly with depressive symptoms regarding their functioning and to ascertain the presence of an association between these symptoms, family functioning and the characteristics of the elderly.
Rosely Almeida Souza, Gislaine Desani da Costa, Cintia Hitomi Yamashita, Fernanda Amendola, Jaqueline Correa Gaspar, Márcia Regina Martins Alvarenga, Odival Faccenda, Maria Amélia de Campos Oliveira   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source