Results 111 to 120 of about 485,517 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Intergenerational Transaction of Emotional Health in Collective Family Context: Family Functioning, Parental and Children’s Gratitude, and Their Depression

Background: The current study is intended to examine how positive family functioning, collectively constructed by parents and children in the family context, may contribute to their gratitude and depression, two pivotal human emotions closely related to ...
Jerf W. K. Yeung
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How can post-COVID care be improved using patient experiences with received care and perceived health? A qualitative study of focus groups with 30 patients having post-COVID in the Netherlands

BMJ Open
Objectives To provide bottom-up guidance on improving post-COVID care using patients’ experiences with received care and their perceived healthDesign Qualitative study design using focus group interviewsParticipants 30 patients with post-COVID condition ...
Jeanine Verbunt, Ivan Huijnen, Jean W M Muris, Jako S Burgers, Onno CP van Schayck, Annerika HM Gidding-Slok, Jeroen Gruiskens, Thijs van Meulenbroek   +7 more
doaj   +1 more source

Health risk behaviors and depressive symptoms among Hispanic adolescents: Examining acculturation discrepancies and family functioning

, 2016
Drawing from a theory of bicultural family functioning 2 models were tested to examine the longitudinal effects of acculturation-related variables on adolescent health risk behaviors and depressive symptoms (HRB/DS) mediated by caregiver and adolescent ...
Lorenzo-Blanco, Elma I, Des Rosiers, Sabrina E, Unger, Jennifer B, Schwartz, Seth J, Villamar, Juan Andres, Baezconde-Garbanati, Lourdes, Lizzi, Karina M, Castillo, Linda G, Huang, Shi, Zamboanga, Byron L, Pattarroyo, Monica, Cano, Miguel Ángel, Szapocznik, José, Romero, Andrea J, Córdova, David, Soto, Daniel W   +15 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The longitudinal study of Australian children annual statistical report 2014 [PDF]

, 2015
Introduction Growing Up in Australia: The Longitudinal Study of Australian Children (LSAC) is Australia\u27s first nationally representative longitudinal study of child development. The purpose of the study is to provide data that enable a comprehensive
Australian Institute of Family Studies
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The role of filial piety and family dysfunction in eating pathology: a cross-sectional and longitudinal study within the Chinese context

Journal of Eating Disorders
Background Family functioning encompasses cultural values and behavioral patterns, with family dysfunction referring to pervasive and maladaptive interactions in the latter dimension.
Xu Han, Mei-chun Cheung, Xueni Li, Lei Yang, Chao Chen   +4 more
doaj   +1 more source

Loneliness, peer acceptance, and family functioning of Chinese children with learning disabilities: Characteristics and relationships

, 2005
Although children with learning disabilities are often considered to be a heterogeneous group, they are always situated in specific social surroundings such as schools and families with which they interact dynamically in everyday life.
Yan, R, Yu, GL, Y. M. Zhang, Zhang, YM
core