Results 131 to 140 of about 4,817,785 (305)
, 2010 Across the generations, family legacies have grown into an Illinois Wesleyan ...
Fields \u2712, Kristin
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Атеросклероз, 2007 Analysis of polymorphism of genes of predisposition to cardiovascular diseases (CVD) in population and prospective study in Novosibirsk. Within the framework of the program MONICA is observed 7111 men and 5523 women from a unorganized population of ...
M. I. Voevoda +9 more
doaj
Northern Town Lot Histories of Fairfield, Pennsylvania
, 2013 Each lot history give the original lot number, original owner, the current address, the owner of the lot in 1860, a description of the lot or dwelling in 1860, a recital of ownership with as much detail as is known, a comprehensive lot history, any known
Smith, Timothy H.
core
'Descended from immigrants and revolutionists': how family immigration history shapes representation in Congress [PDF]
, 2019 Does recent immigrant lineage influence the legislative behavior of members of Congress on immigration policy? We examine the relationship between the immigrant background of legislators (i.e., their generational distance from immigration) and ...
Feigenbaum, James +2 more
core
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Russian Studies in Law and PoliticsThe article represents data from sociological research held in 2021–2023 among the youth of the Arkhangelsk region (Pomorie), characterizing the state and characteristics of civic identity, its relationship to family history, which, in its turn, is ...
Andrey O. Podoplekin
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source