Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
Personality Matters: Owner-Ascribed Personality Predicts Range Size Tendencies and Predation Behavior in Domestic Cats. [PDF]
Ecol EvolBerrand B, Baudry E, Bonnaud E.
europepmc +1 more source
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
The Reproductive and Anatomical Characteristics of the Invasive Nutria (<i>Myocastor coypus</i> M.) in a Central European Population. [PDF]
Animals (Basel)Bócsi B, Biró Z, Katona K.
europepmc +1 more source
Advanced Science, EarlyView.A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Puma habitat preferences when moving and feeding predict the potential for human-carnivore conflict in shared landscapes. [PDF]
Ecol ApplSuraci JP +11 more
europepmc +1 more source
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Back to the Future: Reintroduction into the Wild of the Italian Grey Partridge (<i>Perdix perdix italica</i> Hartert, 1917). [PDF]
Animals (Basel)Riga F +8 more
europepmc +1 more source
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, EarlyView.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
Exploring Indigenous food sovereignty and food environments characteristics through food interventions in Canada: a scoping review. [PDF]
Int J Circumpolar HealthMobetty F +4 more
europepmc +1 more source