Results 141 to 150 of about 2,287 (186)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Society's struggle with unwanted species: what centuries of history reveal about species bounty programs. [PDF]

NPJ Biodivers
Olden JD, Diallo JO, Fricke RM, Jameson E, Johnson RC, Stiling RR, Thompson BK.   +6 more
europepmc   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Over 20,000 precolonial earthworks in the Southwest Amazonia. [PDF]

Nature
Pärssinen M, Kalliola R, Ranzi A, Puttonen E, Lopes RC, Virtanen PK, Apurinã F, Ruokolainen K, Hyyppä J, Kukko A, Campos M, de Novaes F, Oinonen M, Barbosa AD, Saunaluoma S, Ferreira E.   +15 more
europepmc   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

A Scoping Review of the Current Knowledge of the Social Determinants of Health and Infectious Diseases (Specifically COVID-19, Tuberculosis, and H1N1 Influenza) in Canadian Arctic Indigenous Communities. [PDF]

Int J Environ Res Public Health
Kolahdooz F, Jang SL, Deck S, Ilkiw D, Omoro G, Rautio A, Pirkola S, Møller H, Ferguson G, Evengård B, Mantla-Look L, DeLancey D, Corriveau A, Irlbacher-Fox S, Wagg A, Roache C, Rittenbach K, Conter HJ, Falk R, Sharma S.   +19 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Toward a decolonial One Health: Findings from a participatory action research initiative with indigenous, Campesino, and Afro-descendant communities in the Amazon. [PDF]

One Health
Méndez-Paz F, Santandreu A, Betancourt Ó, Burgos A, Mertens F.   +4 more
europepmc   +1 more source

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

Personality Matters: Owner-Ascribed Personality Predicts Range Size Tendencies and Predation Behavior in Domestic Cats. [PDF]

Ecol Evol
Berrand B, Baudry E, Bonnaud E.
europepmc   +1 more source