Results 171 to 180 of about 2,265,049 (313)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Storylines of family medicine II: foundational building blocks-context, community and health

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and ...
Geoffrey M Gusoff, Shah, Rupal, Richard M Frankel, Ventres, William B., A Peter Catinella, Winston Liaw, Bich-May Nguyen, Like, Robert C., Teresa L Schiff-Elfalan, Carter, Tamala, Stone, Leslie A., Zoppi, Kathleen, Frankel, Richard M., Mary Alice Scott, Nguyen, Bich-May, Gusoff, Geoffrey M., William B Ventres, Rachelson, Joanna V., Yamada, Seiji, Rupal Shah, Kathleen Zoppi, Tamala Carter, Liaw, Winston, Shailendra Prasad, Scott, Mary Alice, Schiff-Elfalan, Teresa L., Prasad, Shailendra, Seiji Yamada, Catinella, A. Peter, Joanna V Rachelson, Leslie A Stone, Robert C Like   +31 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Family medicine is our responsibility. [PDF]

Can Fam Physician
Allan M.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Family Medicine Monthly, July 2025

Univerity of Minnesota Department of Family Medicine and Community Health. (2025). Family Medicine Monthly, July 2025.
Univerity of Minnesota Department of Family Medicine and Community Health
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Family Medicine Monthly, May 2025

University of Minnesota Department of Family Medicine and Community Health. (2025). Family Medicine Monthly, May 2025.
University of Minnesota Department of Family Medicine and Community Health
core  

Journal of the Malta College of Family Doctors : volume 6 : issue 2

, 2017
1/ Prof. Fabio PIGOZZI - From the origin to the present : the history of sports and exercise medicine -- 2/ Dr Danica BONELLO SPITERI - Running out of breath -- 3/ Dr Kirill MICALLEF STAFRACE, & Prof.
Mallia, Pierre, Malta College of Family Doctors   +1 more
core