Results 161 to 170 of about 4,197,886 (264)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Building community, not just capacity: International medical graduates and the future of family medicine. [PDF]

Can Fam Physician
Cook S.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Teaching point-of-care ultrasound in a rural family medicine residency. [PDF]

Can Fam Physician
Jones-Delcorde A, Higgins SD, Bhagirath V, Pageau P, Woo MY.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Primary acrocyanosis

Journal of General and Family Medicine, 2021
Yuki Takeuchi, Junji Tsukagoshi
doaj   +1 more source

Care of the elderly: A missed opportunity in Canadian family medicine training? [PDF]

Can Fam Physician
Rossi S, Frank C.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Rural health and Family Medicine

African Journal of Primary Health Care & Family Medicine, 2010
Bernhard M. Gaede
doaj   +1 more source

Z-Drug Use and All-Cause Mortality: A Meta-Analysis of Observational Cohort Studies

Neuropsychiatric Disease and Treatment
Ji-Yeon Park,1 Hye Jin Park,1 Hae-Jin Ko,1,2 A-Sol Kim,2,3 Ji-Eun Song,2,3 Hee-Eun Hong1 1Department of Family Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Family Medicine, School of Medicine, Kyungpook ...
Park JY, Park HJ, Ko HJ, Kim AS, Song JE, Hong HE   +5 more
doaj