Results 151 to 160 of about 4,197,886 (264)

Family medicine is primary care and much more. [PDF]

Can Fam Physician
Allan M, Nash WS.
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Toward a family medicine capability framework for Canada: From competence to capability. [PDF]

Can Fam Physician
Aggarwal M, Scott G, Upshur REG, Katz A, Kulasegaram K.   +4 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Storylines of family medicine XII: family medicine and the healthcare system

Family Medicine and Community Health
Rebecca S Etz, Kurt C Stange, Kendall M Campbell, William L Miller, Thomas Bodenheimer, Robert L Ferrer, Roger Strasser, Joshua Freeman, William B Ventres, Leslie A Stone, Jeannette E South-Paul, Aerial R Petty, Hima Ekanadham, Marianna Kong, Sharon C M Reece, John M Westfall   +15 more
doaj   +1 more source

Voter Engagement in a Family Medicine Residency Clinic. [PDF]

PRiMER
Brown SR, Stauss K, Patel S, Voy C, Dubey S, Langsetmo S, Spielberg F.   +6 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Storylines of family medicine I: framing family medicine – history, values and perspectives

Family Medicine and Community Health
Larry A Green, William B Ventres, Leslie A Stone, Kathleen T Rowland, Richard H Streiffer, Michael D Macechko, Julia A Roulier, Jeffrey M Borkan   +7 more
doaj   +1 more source

The Power of Mentorship in Family Medicine. [PDF]

Fam Med
Marquez C, Rodríguez JE.
europepmc   +1 more source