Results 101 to 110 of about 1,289,589 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Can Spiritual Ecograms be Utilized in Mental Health Services to Promote Culturally Appropriate Family and Couples Therapy with Indigenous People?

, 2012
Research addressing the potential utilization of spiritual ecograms with Indigenous families and children, specified by experienced professional in the field of Native-American psychology, was critiqued and reviewed in order to attend to its influence ...
Elliott, Nicole
core   +1 more source

Does Caregiver Engagement Predict Outcomes of Adolescent Wilderness Therapy?

Behavioral Sciences
Existing research shows some links between wilderness therapy outcomes and familial functioning. However, wilderness therapy programs do not agree on what kind of caregiver involvement is required to improve adolescent program outcomes, nor has research ...
Joanna E. Bettmann, Naomi Martinez Gutierrez, Annelise Jolley, Laura Mills   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Suicide and the Coloniality of the Senses, Time, and Being: The Aesthetics of Death Desires

Social Sciences
We engage the decolonial option from Abya Yala, el Caribe, and Eastern Europe with an interest in suicide from our struggles as racialized people and our dehumanization, whereby, for many of us, suicide is not an act of autonomy or resistance but the ...
marcela polanco, Anthony Pham
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Becoming a Posthuman Systemic Nomad

Murmurations, 2019
We live in a complex, globalised world. Everything is connected and still many of us feel detached, disconnected from other entities on earth. We might sleepwalk into a global ecological crisis and therefore we need to develop new ways of living together
Robert Van Hennik
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Structural-strategic approaches to couple and family therapy

, 2004
Other textbooks on family and couple therapy have had separate chapters for the structural and strategic approaches. In this volume, the two models, structural family therapy, as developed by Salvador Minuchin, and strategic family therapy, as developed ...
Perez, M.A., Behar-Zusman, Victoria, Mitrani, V.B.   +2 more
core   +1 more source

Momentos marcantes na construção da mudança em terapia familiar

Psicologia: Teoria e Pesquisa
Assumindo as contribuições construcionistas sociais, esse estudo visa compreender o processo de produção de sentidos sobre a mudança em terapia familiar.
Emerson F. Rasera, Carla Guanaes
doaj   +1 more source