Results 131 to 140 of about 1,289,589 (309)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Family Therapy for Drug Abuse: Review and Updates 2003-2010
, 2012 Just 15 years ago, Liddle and Dakof (Journal of Marital and Family Therapy, 1995; 21, 511) concluded, based on the available evidence, that family therapy represented a "promising, but not definitive" approach for the treatment of drug problems among ...
Rowe, Cynthia L, Cynthia L. Rowe
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Systemic Trances. Using hypnosis in Family therapy
, 2008 The use of hypnosis with families appears to be an easy and natural process because family provides the most common context for early hypnotic experiences.
LORIEDO, Camillo
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
History of family therapy in Ireland. 1. A bird's-eye view
, 2015 This paper presents an overview of the history of family therapy in Ireland. Profiles of key figures in the development of family therapy in Ireland are contained in a companion paper.
Carr, Alan
core +1 more source
, 2017 Until the late 1960s, the mainstream of psychoanalysis was an asymmetric process in which the psychoanalyst guides the patient out of his/her “neurosis” via the infinite and intense “talking cure” process.
Pietro Barbetta, BARBETTA, Pietro
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From Undereating to Overeating: Family Survival Strategies and Their Consequences
Психология и Психотерапия СемьиThe article provides an overview of the multigenerational transmission process of eating behaviors and habits in Russia. During the mass hunger and food shortages in the 20th century people in Russia learned certain dietary patterns and food psychology ...
Kseniya Novgorodova
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source