Results 101 to 110 of about 89,277,921 (255)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Family Policy, Perceived Stress and Work-Family Conflict A Comparative Analysis of Women in 20 Welfare States [PDF]

In what ways can family policy institutions be linked to women’s perceived stress and work-family conflict? This study combines new institutional information, enabling a multi-dimensional analysis of family policy legislation, with micro data on ...
Esser, Ingrid, Ferrarini, Tommy
core  

Inter-Role Conflict Cycle: Family Distress in Work–Family Dynamics with Job and Home Demands

This study examined the longitudinal relationship between work–family conflict (WFC) and family–work conflict (FWC), with a focus on the moderating role of job demands and home demands, and the mediating role of family distress within dyads (i.e., actor [
Idris, Mohd Awang, Ratnaningsih, Ika Zenita   +1 more
core   +1 more source

Effort-reward imbalance influences perceived patient safety during the COVID-19 pandemic, mediated by work-family conflict: results from the longitudinal VOICE study

Frontiers in Organizational Psychology
BackgroundThe COVID-19 pandemic increased psychosocial burden on healthcare workers, especially related to work-family conflict, leading to significant health consequences.
Lucia Jerg-Bretzke, Paul Platzek, Marc N. Jarczok, Maximilian Kempf, Katja Weimer, Christian Hirning, Sarah Kern, Franziska Geiser, Andreas Baranowski, Yesim Erim, Eva Morawa, Kerstin Weidner, Susann Steudte-Schmiedgen, Christian Albus, Petra Beschoner   +14 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The relationship between family-focused organisational and supervisor support and positive work-outcomes [PDF]

, 2010
This study examined the relationship between family-focused organisational and .supervisor support and the positive work outcomes, job satisfaction, affective commitment, continuous commitment and work-family ...
Mohasi, Mapalo
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

How Guilt Drives Emotional Exhaustion in Work–Pet Family Conflict

Animals
Work–pet family conflict has emerged as a novel form of work–life conflict, reflecting the increasingly significant role that pets play in modern families.
Ana Junça-Silva
doaj   +1 more source