Results 31 to 40 of about 328 (208)

Famine in the young and risk of later hospitalization for COPD and asthma. [PDF]

PLoS ONE, 2013
BACKGROUND: Undernutrition during critical periods of growth and development may permanently affect lung physiology and function. OBJECTIVES: To investigate whether acute undernutrition in childhood or young adulthood increases the risk of later ...
Annet F M van Abeelen, Sjoerd G Elias, Pim A de Jong, Diederick E Grobbee, Patrick M M Bossuyt, Yvonne T van der Schouw, Tessa J Roseboom, Cuno S P M Uiterwaal   +7 more
doaj   +1 more source

Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine [PDF]

The American Journal of Clinical Nutrition, 2007
Few studies in humans have related maternal undernutrition to the size of the adult offspring.The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age.We recruited 1) exposed persons born in western Netherlands ...
Stein, A.D., Kahn, H.S., Rundle, A., Zybert, P.A., Pal-de Bruin, K.M. van der, Lumey, L.H.   +5 more
openaire   +3 more sources

Impact of early life famine exposure on adulthood anthropometry among survivors of the 1983–1985 Ethiopian Great famine: a historical cohort study

BMC Public Health, 2021
Background Nutritional insult in early life brings adaptive changes in body structure and functioning that could remain throughout the affected individual’s life course.
Getachew Arage, Tefera Belachew, Kemal Hajmahmud, Mubarek Abera, Fedilu Abdulhay, Misra Abdulahi, Kalkidan Hassen Abate   +6 more
doaj   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases

BMC Medicine
Background Exposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic resonance (NMR) metabolomic profiling to identify the metabolic changes ...
M. Jazmin Taeubert, Thomas B. Kuipers, Jiayi Zhou, Chihua Li, Shuang Wang, Tian Wang, Elmar W. Tobi, BBMRI-NL Metabolomics consortium, Daniel W. Belsky, L. H. Lumey, Bastiaan T. Heijmans   +10 more
doaj   +1 more source

Gestational exposure to the great Chinese famine: early life undernutrition impact on prostatic hyperplasia in adulthood

Frontiers in Nutrition
IntroductionBenign prostatic hyperplasia (BPH) is a frequent illness in aged men that impacts their quality of life; early childhood exposure to famines may have long-term effects on the chance of developing BPH.
Siyao Wang, Yong Zhang, Yong Zhang, Xiaoya Qi, Xiaoyang Xu   +4 more
doaj   +1 more source

Exposure to the Chinese famine in early life and the risk of anaemia in adulthood [PDF]

BMC Public Health, 2013
Famine exposure during the early stage of life is related to a number of adulthood diseases. The objective of this study was to examine the association of early life exposure to the famine in China (1959-1961) with the risk of anaemia in adulthood.We used the data of 2007 adults born between 1954 and 1964 in Jiangsu province from the 2002 Chinese ...
Shi, Z., Zhang, C., Zhou, M., Zhen, S., Taylor, A.   +4 more
openaire   +3 more sources

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu, Masaharu Akiyama, Toshikazu Itabashi, Jun Hayakawa, Takahiro Kikuchi, Ryohei Fukunaga, Katsuyoshi Koh, Takahiro Ueda   +7 more
wiley   +1 more source

Metabolites in the association between early-life famine exposure and type 2 diabetes in adulthood over a 5-year follow-up period

BMJ Open Diabetes Research & Care, 2021
Introduction Exposure to malnutrition in early life has been found to significantly elevate type 2 diabetes risk in adulthood. However, the changes in metabolites resulting from malnutrition in early life have not been studied.
Wen Zhang, Ningjian Wang, Yingli Lu, Chi Chen, Fangzhen Xia, Yuying Wang, Heng Wan   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source