Results 41 to 50 of about 67,215 (287)

Early-life exposure to Chinese famine and stroke risk in mid- to late life: the mediating roles of cognitive function and depression

BMC Geriatrics, 2022
Background Limited research has examined the role that famine exposure plays in adulthood stroke risk. We aim to explore the causal implications of early exposure to the Great Chinese Famine on stroke risk and determine whether these associations were ...
Zi Zhou, Wei Zhang, Ya Fang
doaj   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE, Dominguez-Salas, P, Hennig, BJ, Moore, SE, Prentice, AM   +4 more
core   +4 more sources

Impaired Insulin Secretion After Prenatal Exposure to the Dutch Famine [PDF]

Diabetes Care, 2006
OBJECTIVE—We previously reported that people prenatally exposed to famine during the Dutch Hunger Winter of 1944–1945 have higher 2-h glucose concentrations after an oral glucose tolerance test in later life. We aimed to determine whether this association is mediated through alterations in insulin secretion, insulin sensitivity, or a combination of ...
de Rooij, Susanne R., Painter, Rebecca C., Phillips, David I.W., Osmond, Clive, Michels, Robert P.J., Godsland, Ian F., Bossuyt, Patrick M.M., Bleker, Otto P., Roseboom, Tessa J.   +8 more
openaire   +4 more sources

Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood [PDF]

International Journal of Environmental Research and Public Health, 2020
Undernutrition in early life may have a long consequence of type 2 diabetes in adulthood. The current study was aimed to explore the association between famine exposure in fetal life during China’s Great Famine (1959–1961) and dysglycemia in adulthood.
Yan Zhang, Chao Song, Meng Wang, Weiyan Gong, Yanning Ma, Zheng Chen, Ganyu Feng, Rui Wang, Hongyun Fang, Jing Fan, Ailing Liu   +10 more
openaire   +2 more sources

Increase in the prevalence of hypertension among adults exposed to the Great Chinese Famine during early life

Environmental Health and Preventive Medicine, 2017
Objective This study aimed to assess the association between exposure to the Great Chinese Famine (1959–1961) during early life and hypertension in adulthood.
Lingli Liu, Xianglong Xu, Huan Zeng, Yong Zhang, Zumin Shi, Fan Zhang, Xianqing Cao, Yao Jie Xie, Cesar Reis, Yong Zhao   +9 more
doaj   +1 more source

Famine in the young and risk of later hospitalization for COPD and asthma. [PDF]

PLoS ONE, 2013
BACKGROUND: Undernutrition during critical periods of growth and development may permanently affect lung physiology and function. OBJECTIVES: To investigate whether acute undernutrition in childhood or young adulthood increases the risk of later ...
Annet F M van Abeelen, Sjoerd G Elias, Pim A de Jong, Diederick E Grobbee, Patrick M M Bossuyt, Yvonne T van der Schouw, Tessa J Roseboom, Cuno S P M Uiterwaal   +7 more
doaj   +1 more source

Late-life brain perfusion after prenatal famine exposure [PDF]

Neurobiology of Aging, 2019
Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labeling scans in 118 Dutch famine birth cohort members.
Rooij, S. R., Mutsaerts, H. M., Petr, J., Asllani, I., Caan, M. W., Groot, P., Nederveen, A., Schwab, M., Roseboom, T. J.   +8 more
openaire   +3 more sources

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort [PDF]

, 2013
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic ...
A Kerjean, A Murrell, A Soubry, AD Stein, Adelheid Soubry, Amy Murtha, AP Feinberg, Autumn Bernal, BE Levin, BR Carone, BT Heijmans, C Gemma, C Gicquel, C Hoyo, C Hoyo, Cathrine Hoyo, CC Boissonnas, DC Dolinoy, DC Dolinoy, DJ Barker, Frances Wang, G Kaati, GA Dunn, GP Ravelli, H Boerschmann, H Cui, H Cui, H Cui, J Baker, J Frystyk, JA McKay, Joanne Kurtzberg, Joellen M Schildkraut, JS Dyer, KJ Stothard, LM McCowan, M Braunschweig, M Cruz-Correa, M Ollikainen, ME Pembrey, ME Pembrey, MJ Steenman, MJ Sullivan, Q Wu, R Barres, R Figueroa-Colon, R Loomba, RA Waterland, RA Waterland, RA Waterland, Randy L Jirtle, RC Painter, RC Painter, RL Jirtle, RP Steegers-Theunissen, S Honda, S Katari, S Pathak, SA Tanumihardjo, SD McDonald, SF Ng, SK Murphy, SK Murphy, SK Murphy, SS Du Plessis, Susan K Murphy, W Chao, Z Huang, Zhiqing Huang   +68 more
core   +3 more sources

Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine [PDF]

The American Journal of Clinical Nutrition, 2007
Few studies in humans have related maternal undernutrition to the size of the adult offspring.The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age.We recruited 1) exposed persons born in western Netherlands ...
Stein, A.D., Kahn, H.S., Rundle, A., Zybert, P.A., Pal-de Bruin, K.M. van der, Lumey, L.H.   +5 more
openaire   +3 more sources

Impact of early life famine exposure on adulthood anthropometry among survivors of the 1983–1985 Ethiopian Great famine: a historical cohort study

BMC Public Health, 2021
Background Nutritional insult in early life brings adaptive changes in body structure and functioning that could remain throughout the affected individual’s life course.
Getachew Arage, Tefera Belachew, Kemal Hajmahmud, Mubarek Abera, Fedilu Abdulhay, Misra Abdulahi, Kalkidan Hassen Abate   +6 more
doaj   +1 more source