Results 71 to 80 of about 603,323 (290)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
FAN LOYALTY IN CASES OF LOW SPORT PERFORMANCE – HOW MUCH IS TOO MUCH? [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria EconomieSport is one of the most precious elements of life. And sports competitions are part of human nature. Since ancient times, people have organized contests and eagerly awaited the outcome. Why is fan loyalty such an important factor?
POPA MARIAN GABRIEL +5 more
doaj
Esports buffs: the perceived role of fans and fandoms in U.S. collegiate programs
Frontiers in Sports and Active LivingIntroductionCollegiate esports—organized competitive gaming—has expanded rapidly in the United States, drawing in student players, broadcasters, and support staff, as well as university employees. Universities have invested financially in esports, hoping
Amanda C. Cote +13 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
A INDÚSTRIA 4.0 E AS INOVAÇÕES EM SUPRIMENTOS
Faces: Revista de AdministraçãoO departamento de suprimentos de uma empresa é o responsável por atender as necessidades organizacionais com o intuito de gerar a integração e o desenvolvimento da organização.
Frederico Cesar Mafra Pereira +2 more
doaj
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Revue Française des Sciences de l’Information et de la Communication, 2017 Under many circumstances, fan works do not merely add to a central commercial narrative, but instead become the definitive version of « what really happened » for some members of the audience.
Anne Kustritz
doaj +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source