Results 71 to 80 of about 726,293 (345)

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen   +13 more
wiley   +1 more source

A systematic approach toward progressive improvement of national antimicrobial resistance surveillance systems in food and agriculture sectors

open access: yesFrontiers in Veterinary Science, 2023
The first Food and Agriculture Organization of the United Nations (FAO) Action Plan on antimicrobial resistance (AMR), published in 2016, identified the need to develop capacity for AMR surveillance and monitoring in food and agriculture sectors. As part
Nicolas Keck   +13 more
doaj   +1 more source

Towards development of a report on the state of the world's forest genetic resources [PDF]

open access: yes, 2008
La disponibilité de données fiables est indispensable pour la conservation efficace et la gestion durable des ressources génétiques forestières. À ce jour, il n'existe aucune vision globale de l'état et de l'évolution de ces ressources, ni d'estimations ...
Palmberg-Lerche, Christel   +1 more
core  

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

open access: yesAdvanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong   +13 more
wiley   +1 more source

Active Protection Technology of Depot Automatic Zones in Urban Rail Transit FAO Vehicle Base

open access: yesChengshi guidao jiaotong yanjiu
[Objective] Setting up underpass or overpass in front or inside the urban rail transit depot for personnel's access to the automatic zone requires large project investment, being prone to affect personnel evacuation and cause safety hazards due to the ...
Zhengyuan ZHANG
doaj   +1 more source

Strategic Review of Tropical Fisheries Management [PDF]

open access: yes, 2002
This project addresses the constraints to tropical fisheries development with sustainable exploitation through a strategic assessment of tropical fisheries management with the following purposes: (1) To evaluate relevant research methods for the ...
A. S. Halls   +4 more
core  

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

open access: yesAdvanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang   +8 more
wiley   +1 more source

FAO Training Workshop on "Epidemiology, surveillance, outbreaks investigation and training engineering in epidemiological field", U Choice Hotel, Lunming - China, 29th june-9th july 2009 : Mission report [PDF]

open access: yes, 2009
Cet atelier a été organisé par la FAO en collaboration avec le CIRAD et les services vétérinaires chinois. La formation a été divisée en deux parties distinctes: la première avait pour objectif de renforcer les capacités des agents des services ...
Desvaux, Stéphanie   +2 more
core  

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng   +9 more
wiley   +1 more source

Use of Indicators to Evaluate Sustainability of Animal Production Systems [PDF]

open access: yes, 2006
SUMMARY – Few indicators for sustainability are used in studying animal production systems. Sustainability of these systems should be evaluated in a dynamic and multidisciplinary manner, and those indicators used should allow for detecting the systems'
Castel Genís, José María   +3 more
core  

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