Results 91 to 100 of about 64,984 (332)

Additional file 1 of Autophagy inhibition improves the targeted radionuclide therapy efficacy of 131I-FAP-2286 in pancreatic cancer xenografts

Additional file 1: Figure S1. (A-B) Representative western blot image and the semi-quantification analysis of p62 expression in PANC-1 cells. I, Control; II, 131I-FAP-2286; III, 131I-FAP-2286 + indirect coculture with CAFs (1: 1); IV, 131I-FAP-2286 ...
Changjing Zuo (17975623), Xiu Luo (246167), Ye Peng (320691), Tao Wang (12008), Danni Li (1431700), Xingyu Liu (1528789), Jianming Cai (9945442), Tianbao Ma (3366986)   +7 more
core   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Family Adoption Program: An NMC-mandated Initiative

Indian Journal of Community Medicine
The National Medical Commission (NMC) of India has introduced the Family Adoption Program (FAP) as a key initiative within the Competency-Based Medical Education (CBME) framework.
Hemangini Kishore Shah, Amrit Kaur Virk, Amol Dongre, Shib Shekhar Datta, Subodh S. Gupta   +4 more
doaj   +1 more source

Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis

The Application of Clinical Genetics, 2023
Filippos Kyriakidis,1,* Dionysios Kogias,2,* Theodora Maria Venou,1,* Eleni Karlafti,3,4 Daniel Paramythiotis5 1Second Chemotherapy Department, Theagenio Cancer Hospital of Thessaloniki, Thessaloniki, Greece; 2First Department of Internal ...
Kyriakidis F, Kogias D, Venou TM, Karlafti E, Paramythiotis D   +4 more
doaj  

Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration

Journal of Nanobiotechnology
Osteoarthritis (OA) is a common joint disease that leads to chronic pain and functional limitations. Recent research has revealed soluble fibroblast activation protein (FAP) secreted from OA synovium could degrade type II collagen (Col2) in cartilage to ...
Xiang Zhao, Jieming Lin, Mingyang Liu, Dongxin Jiang, Yu Zhang, Xin Li, Bo Shi, Jun Jiang, Chunhui Ma, Hongda Shao, Qingrong Xu, Huang Ping, Jiajin Li, Yan-Zheng Gao   +13 more
semanticscholar   +1 more source

sj-docx-1-fap-10.1177_09593535221101456 - Supplemental material for Mother blaming and anorexia: How ideological state apparatuses have informed my perception of my mother's role in the formation of my eating disorder

, 2022
Supplemental material, sj-docx-1-fap-10.1177_09593535221101456 for Mother blaming and anorexia: How ideological state apparatuses have informed my perception of my mother's role in the formation of my eating disorder by Oxana Mikhaylova in Feminism ...
Oxana Mikhaylova (12431364)
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Frecuencia de diagnósticos de la especialidad de otorrinolaringología en el consultorio de medicina general en un centro de salud

Revista Médica Herediana, 2003
Objetivos: Determinar la frecuencia de los diagnósticos por especialidad en consulta externa de medicina general y describir los diagnósticos más frecuentemente realizados dentro de la especialidad de otorrinolaringología.
Lizeth Diaz Ledesma, Jorge Humberto Davila Acosta, Victor Manuel Rodriguez Salazar, Dirck Martin Añaños Flores   +3 more
doaj  

Apropriação indevida de palavras articuladas em textos científicos: a justiça restaurativa como possibilidade de resolução dos conflitos gerados

Sequência: Estudos Juridicos e Politicos, 2019
De discursos de autoridades a trabalhos científicos, a apropriação indevida de palavras tem deixado em alerta a comunidade acadêmica no tocante à ética na escrita da academia.
Adriana de Alencar Gomes Pinheiro, Roberta Marina Cioatto   +1 more
doaj   +1 more source

Initial Experience with 68Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer

Journal of Nuclear Medicine
Visual Abstract Improved imaging modalities are needed to accurately stage patients with muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma.
V. Koshkin, Vipul Kumar, Brad Kline, D. Escobar, Maya Aslam, M. Cooperberg, Rahul R. Aggarwal, I. de Kouchkovsky, Jonathan Chou, Maxwell V. Meng, T. Friedlander, S. Porten, T. Hope   +12 more
semanticscholar   +1 more source