Results 111 to 120 of about 64,984 (332)

sj-docx-1-fap-10.1177_09593535231217135 - Supplemental material for The practical realization of the feminist welfare state: Equal sharing and gender equality in institutional interaction about parental leave in Sweden

, 2023
Supplemental material, sj-docx-1-fap-10.1177_09593535231217135 for The practical realization of the feminist welfare state: Equal sharing and gender equality in institutional interaction about parental leave in Sweden by Frida Höglund and Marie ...
Marie Flinkfeldt (10098076), Frida Höglund (17697904)   +1 more
core   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

DC-shA20-FAP-TRP2 vaccine has potent antitumor activity.

, 2013
(A) RT-PCR for FAP and GAPDH of B16 cell line, and day 5 B16 tumors. (B,C) Mice were inoculated with B16 followed by immunization with 1×106 DC-shA20-FAP (AF), DC-shA20-TRP2 (AT), DC-shA20-FAP-TRP2 (AFT), DC-shCo-FAP-TRP2 (ACT) or PBS on day 5 (n =  5 ...
Xiao-Tong Song (72217), Sunitha Kakarla (496460), Minjun Ji (135275), Feng Yu (273443), Stephen Gottschalk (220269)   +4 more
core   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair [PDF]

Ji-Young Kang,1 Dasom Mun,1 Malgeum Park,1 Gyeongseo Yoo,2 Hyoeun Kim,3 Nuri Yun,4 Boyoung Joung1,2 1Division of Cardiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; 2Graduate School of Medical Science, Brain Korea 21 ...
Joung B, Kim H, Kang JY, Park M, Mun D, Yoo G, Yun N   +6 more
core  

Supplementary Figure S1, Table S1, and Table S2 from RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

, 2016
Figure S1. Related to Figure 1. Characterization of FAP-drozitumab BsAbs and antitumor efficacy in the presence of FAP-expressing fibroblasts in in vitro co-culture models; Table S1. BsAb binding to DR5 and FAP antigens; Table S2.
Peter Brünker (14942754), Ralf J. Hosse (14994968), Ningping Feng (3397070), Frank Herting (279763), Barbara Weiser (3482042), Kathryn Packman (93334), Sandra Grau-Richards (14994977), Cuiying Shao (15073915), Huifeng Niu (144889), Suzana Vega-Harring (14988911), Claudia Ferrara Koller (15073909), Meher Majety (23784), Katharina Wartha (15073906), Valeria Runza (3147225), Werner Scheuer (279759), Ekkehard Mössner (15073912), Gary Xu (15073918), Klaus Bosslet (3021141), Peng Wang (34436), Bin Liu (5899), Christian Klein (121710), Thomas G. Weber (14915118), Inja Waldhauer (13507033), Thomas Friess (3147213), Hadassah Sade (556713), Pablo Umaña (9706199), Sherif Daouti (14895990)   +26 more
core   +1 more source

Image1_Cell-specific expression of the FAP gene is regulated by enhancer elements.pdf

, 2023
Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Eugene D. Sverdlov (8763489), Irina V. Alekseenko (14578448), Elena S. Kotova (14578436), Dina V. Antonova (14578430), Dmitry A. Gnatenko (14578433), Alexey I. Kuzmich (14578442), Dmitry A. Didych (14578445), Victor V. Pleshkan (14578439)   +7 more
core   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Research Progress of Radionuclide-Labeled Small Molecule FAP Inhibitors in Tumor Diagnosis and Treatment

Journal of Isotopes, 2022
At present, one of the difficulties in the clinical diagnosis and treatment of tumors is to find specific targets and highly selective targeted inhibitors.
LIU Jingru;RUI Jiangzhong;ZHU Hong
doaj  

The Functional Effect of Fas-Associated Phosphatase(FAP-1) on Keratin 8/18 in Hepatocytes

, 2013
Fas-associated phosphatase-1 (FAP-1)屬於非受器型酪胺酸去磷酸酶(non-receptor protein tyrosine phosphastase)的一員，本實驗室先前利用positional cloning的方法發現FAP-1可能是一個位於chromosome 4q21-23上，參與肝癌形成的putative candidate tumor suppressor gene (TSG)，但目前仍不清楚FAP-1在肝癌形成過程中的功能性影響為何。因為FAP ...
Lai, Ya-Yun, 賴亞筠
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