Results 41 to 50 of about 4,372 (281)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Probabilistic seismic response and uncertainty analysis of continuous bridges under near-fault ground motions

, 2019
Performance-based seismic design can generate predictable structure damage result with given seismic hazard. However, there are multiple sources of uncertainties in the seismic design process that can affect desired performance predictability. This paper
Marano, Giuseppe Carlo, Zhuo, Wei Dong, Gabriele Fiorentino, Hai-Bin Ma, Camillo Nuti, Ma, Hai Bin, Fiorentino, Gabriele, Wei-Dong Zhuo, Giuseppe Carlo Marano, Bruno Briseghella, Davide Lavorato, Greco, Rita, Lavorato, Davide, Nuti, Camillo, Briseghella, Bruno, Rita Greco   +15 more
core   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Moderators of the Effects of Exercise and Manual Therapy for People With Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate potential moderators influencing the effects of manual therapy and exercise therapy on pain and functional outcomes in individuals with knee and/or hip osteoarthritis, using data from the MOA trial. This is a secondary analysis of data from the MOA trial that compares the clinical effectiveness of manual ...
Daniel Cury Ribeiro, Sarah E. Lamb, J. Haxby Abbott   +2 more
wiley   +1 more source

EFFECTS OF NEAR-FAULT AND FAR-FAULT GROUND MOTIONS ON SEISMIC PERFORMANCE OF 5-STORY R/C BUILDING [PDF]

European Journal of Technic, 2017
Yapılan çalışmada, konut tipi bir yapının ülkemizde kullanılmakta olan deprem yönetmeliğine (DBYBHY-2007) göre deprem performansı incelenmiştir. Güncel çalışmalarda sıkça ele alınan yakın fay ve uzak fay etkilerinin deprem performansı incelemesindeki etkisi irdelenmiştir.
AKDOĞAN, Rehber, KARAŞİN, A.Halim
openaire   +2 more sources

Impact of Near-Fault Ground Motions on Longitudinal Seismic Response of CHRF Bridges

, 2022
Curved high-pier rigid frame bridges (CHRF bridges) are unavoidably affected by near-fault ground motions (NFGMs), and seismic pounding between adjacent components of CHRF bridge has a significant effect on the seismic performance of CHRF bridges.
Yongrui Zheng, Nana Li, Jin Wang, Yanjiang Chen, Weibing Xu, Wenxue Zhang   +5 more
core   +1 more source

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source

Assessment of Spectrum Modification Factor for Design of Steel Moment Frames in Near Fault Regions [PDF]

Journal of Structural and Construction Engineering, 2018
Iranian Seismic design code (standard No. 2800) increases the design spectrum ordinates by a modification factor (N factor), to consider the damaging effects of near fault ground motions in design procedure of structures.
Reza Vahdani, Mohsen Gerami, Morteza Razi   +2 more
doaj   +1 more source

Microstructure Evolution of a VMnFeCoNi High‐Entropy Alloy After Synthesis, Swaging, and Annealing

Advanced Engineering Materials, EarlyView.
The synthesis and processing (rotary swaging and annealing) of the novel VMnFeCoNi alloy is investigated, alongside the estimation of the grain size effect on hardness. Analysis of a wide grain size range of recrystallized microstructures (12–210 µm) reveals a low annealing twin density.
Aditya Srinivasan Tirunilai, Zeki Ayrildi, Buse Şen, Maik Rajkowski, Mathias Redondo Garcia, Markus Stricker, Guillaume Laplanche   +6 more
wiley   +1 more source

Effects of Near Fault and Far Fault Ground Motions on Nonlinear Dynamic Response and Seismic Improvement of Bridges

Civil Engineering Journal, 2018
In this study, the dynamic response of bridges to earthquakes near and far from the fault has been investigated. With respect to available data and showing the effects of key factors and variables, we have examined the bridge's performance. Modeling a two-span concrete bridge in CSI Bridge software and ability of this bridge under strong ground motion ...
Mohammad Hajali, Abdolrahim Jalali, Ahmad Maleki   +2 more
openaire   +2 more sources