Results 41 to 50 of about 3,903,989 (306)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Introductory Guide To Understanding Misogyny And The Far-Right

open access: yes, 2023
The right-wing spectrum consists of many sub-variants of ideology; however, all actors in the right-wing landscape are – to varying degrees – ‘right of’ centre on the political spectrum.
Jessica White (16020963)   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Neither demarcation nor confrontation

open access: yesZeitschrift für Weiterbildungsforschung - Report, 2020
Right-wing populism has strongly polarizing effects in politics, education and science—a problem which this article aims to adress. Instead of claiming a demarcation between science and education on the one hand and right-wing populist ideology on the ...
Christoph Haker, Lukas Otterspeer
doaj   +1 more source

The Emotional Dimension of the Spanish Far Right and Its Effects on Satisfaction with Democracy

open access: yesSocial Sciences, 2022
The recent rise of the far right in Spain highlights the importance of analysing the elements that have contributed to VOX’s success and the party’s ascent to the third political power in the country after the general election held in November 2019.
Erika Jaráiz Gulías   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

‘Centre right? What centre right?’ Italy’s right-wing coalition: Forza Italia’s political ‘heritage’ and the mainstreaming of the far right

open access: yes, 2022
The coalition between Fratelli d’Italia, Lega, Forza Italia and some minor allies is expected to win the Italian general election on 25 September 2022 by a considerable margin, at least according to all the opinion polls.
Valerio Alfonso Bruno
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The (far-) right kind of feeling

open access: yesJournalistica
The growth of far-right alternative news media and its influence on political debate highlights the need to understand the role of emotions in this type of media.
Magnus Danielson
doaj   +1 more source

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