Results 41 to 50 of about 1,198,070 (304)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Designing for the Far Right [PDF]
, 2019 A new book from Steven Heller examines the history of the symbols used by the far right. Here, he talks to Daniel Cookney about why these designs have proved so enduring, and also advocates for why they should be ...
Cookney, DJ
core +1 more source
Mimicking news: how the credibility of an established tabloid is used when disseminating racism [PDF]
, 2020 This article explores the mimicking of tabloid news as a form of covert racism, relying on the credibility of an established tabloid newspaper. The qualitative case study focuses on a digital platform for letters to the editor, operated without editorial
Farkas, Johan, Neumayer, Christina
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Finding the far right online: an exploratory study of white supremacist websites [PDF]
, 2009 White supremacists and the Far Right political movement in the UK have, had considerable success in spreading their messages through Web sites. Some of these Web sites clearly contribute to an enabling environment for racially motivated violence in our ...
Sutton, M, Wright, C
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The (far-) right kind of feeling
JournalisticaThe growth of far-right alternative news media and its influence on political debate highlights the need to understand the role of emotions in this type of media.
Magnus Danielson
doaj +1 more source
Why the Cameron-Clegg coalition will be a shock to both Tory and Liberal Democrat voters [PDF]
, 2010 There has been intensive speculation about how Conservative and Liberal Democrat voters will react to the coalition government cemented in their name.
Norris, Pippa
core
The Alt-Right and Global Information Warfare [PDF]
, 2019 The Alt-Right is a neo-fascist white supremacist movement that is involved in violent extremism and shows signs of engagement in extensive disinformation campaigns.
Bevensee, Emmi, Ross, Alexander Reid
core +3 more sources