Results 51 to 60 of about 3,903,989 (306)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Political ecologies of the far right
The edited volume Political ecologies of the far right engages with the alarming convergence of far-right thinking and the ecological crisis in contemporary society.
core +1 more source
Tilting at Windmills Opportunistically: The Case of Georgian Far Right [PDF]
Ethno-religious nationalism has been an integral part of the Georgian identity since the country regained independence. Since the early 2000s, Georgia has had a constitutionally enshrined pro-European foreign policy, which has been reflected in a strong ...
Gelovani, Shota
core +1 more source
When The Far-Right Reads Lacan
Studia Universitatis Babeș-Bolyai. PhilosophiaThis article examines the recent appropriation of Lacanian Psychoanalysis by Aleksandr Dugin, who utilizes Lacan as a resource for nationalist and illiberal politics.
Octavian-Ionuț OJOG
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Right to Die with Dignity ::How Far Do Human Rights Extend? /
, 2022 "Can I choose to die?" As the number of requests for euthanasia and physician-assisted suicide continues to rise, human rights law faces a new conflict: the right to die vs. the right to life...
Kayacan, Derya Nur,, Kayacan, Derya Nur
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Far-right narratives of climate change acceptance and their role in addressing climate skepticism
, 2023 As research on far-right climate change communication focuses on climate skepticisms, little is known about how the far-right justifies climate acceptance—and what this might mean for environmental education and counter-communication.
Balša Lubarda (17085505) +1 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source