Results 81 to 90 of about 9,704,193 (294)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Sound pressure radiation of a circular piston located at a two- and three-wall corners

Archives of Acoustics, 2014
This paper focuses on the far field approximation of the steady state sound pressure radiated by a flat circular piston into the region bounded by some flat rigid baffles.
Wojciech P. RDZANEK, Krzysztof SZEMELA, Dawid PIECZONKA   +2 more
doaj  

Closed-Form Expressions for LoS User Localization at an Uniform Linear Array Applicable to Both Near-Field and Far-Field

IEEE Access
We present a scheme for line-of-sight user localization at a uniform linear array (ULA) applicable to both near-field and far-field. The proposed scheme leads to closed-form expressions for the estimates of the user location, distance and angle.
Nikola Zlatanov, Manjesh Kumar Hanawal, Alexey Frolov, Kirill Andreev   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Optimization of Far-Field Antenna Range [PDF]

Radioengineering, 2015
Measurements of test antennas are performed on antenna ranges. The operated microwave far-field outdoor range was built-up in 1970’s and therefore it was not appropriate for the today measurements.
O. Cerny, R. Dolecek, P. Kopecky, V. Schejbal, V. Zavodny   +4 more
doaj  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Phase Centre Determination on the Basis of Far-Field Measurements

, 2009
In this paper we investigate the phase centre variations of an antenna array used with a GNSS receiver for beamforming. For the determination of the carrier and code phase centres of the antenna array both simulated and measured far-field radiation ...
Basta, Nikola, Konovaltsev, Andriy, Greda, Lukasz   +2 more
core  

Far-field measurement of proposed dual band two port MIMO antenna.

Far-field measurement of proposed dual band two port MIMO antenna.
Wahaj Abbas Awan (14203771), Fahd Alsaleem (18397706), Tanvir Islam (8561754), Fahad N. Alsunaydih (18397703), Khaled Alhassoonc (18397709)   +4 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source