Results 51 to 60 of about 1,157,153 (352)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The (far-) right kind of feeling
JournalisticaThe growth of far-right alternative news media and its influence on political debate highlights the need to understand the role of emotions in this type of media.
Magnus Danielson
doaj +1 more source
Political ecologies of the far right
The edited volume Political ecologies of the far right engages with the alarming convergence of far-right thinking and the ecological crisis in contemporary society.
core +1 more source
Tilting at Windmills Opportunistically: The Case of Georgian Far Right [PDF]
Ethno-religious nationalism has been an integral part of the Georgian identity since the country regained independence. Since the early 2000s, Georgia has had a constitutionally enshrined pro-European foreign policy, which has been reflected in a strong ...
Gelovani, Shota
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Right to Die with Dignity ::How Far Do Human Rights Extend? /
, 2022 "Can I choose to die?" As the number of requests for euthanasia and physician-assisted suicide continues to rise, human rights law faces a new conflict: the right to die vs. the right to life...
Kayacan, Derya Nur,, Kayacan, Derya Nur
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Far Right in Western Europe: “From the Margins to the Mainstream” And Back?
Cuadernos Europeos de Deusto, 2018 This paper analyses the rise of the Far Right in Western Europe and the widespread political, social and scholarly concern due to the extremist parties’ recent electoral performances. It holds that, already since the late 1980s, we are witnessing a new (
Beatriz Acha Ugarte
doaj +1 more source