Results 41 to 50 of about 1,334 (146)

Effects of VEGFA and ANGPT2 Antibodies on the Activation of Microglia in the Early Stages of Streptozotocin‐Induced Pathogenesis of Diabetic Retinopathy

Genes to Cells, Volume 30, Issue 4, July 2025.
ABSTRACT Diabetic retinopathy (DR) is known as a microvascular complication, in which various inflammatory symptoms, including activation of microglia, are observed. A model of hyperglycemia resembling type 1 diabetes mellitus (DM) induced in mice by intraperitoneal injection of streptozotocin (STZ) has been widely used. We examined the effects of anti‐
Toshiro Iwagawa, Yuta Inokuchi, Kosuke Saita, Tetsuhiro Soeda, Ayumi Usui‐Ouchi, Makoto Aihara, Sumiko Watanabe   +6 more
wiley   +1 more source

Unravelling T cell exhaustion through co‐inhibitory receptors and its transformative role in cancer immunotherapy

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
This review discusses five major co‐inhibitory receptors (PD‐1, CTLA‐4, LAG‐3, TIM‐3 and TIGIT) and their related mechanisms of T cell exhaustion in the tumour environment. We also discuss the clinical application of checkpoint inhibitors (ICIs) in cancer immunotherapy.
Simin Xiang, Sen Li, Junfen Xu
wiley   +1 more source

Comparative efficacy and safety of Faricimab with other intravitreal anti-vascular endothelial growth factor in the treatment of Neovascular age related macular degeneration- A Systematic review and meta-analysis

Asian Journal of Medical Sciences
Age-related macular degeneration (AMD) is the leading cause of visual impairment in patients age 50 and older, with an estimated 200 million people affected worldwide.
Renuga Devi Kaliaperumal , Nandhini P, Reena Mohan , Nallamuthu P , Jenifer Florence Mary J   +4 more
doaj   +1 more source

Hereditary Vitreoretinopathies: Molecular Diagnosis, Clinical Presentation and Management

Clinical &Experimental Ophthalmology, Volume 53, Issue 3, Page 281-291, April 2025.
ABSTRACT Hereditary vitreoretinopathies (HVRs), also known as hereditary vitreoretinal degenerations comprise a heterogeneous group of inherited disorders of the retina and vitreous, collectively and variably characterised by vitreal abnormalities, such as fibrillary condensations, liquefaction or membranes, as well as peripheral retinal abnormalities,
Hashem H. Ghoraba, Jonathan Sears, Elias I. Traboulsi   +2 more
wiley   +1 more source

Real-World Data on Morphological and Functional Responses After Switching to Faricimab in Recalcitrant, Chronic Diabetic Macular Edema

Ophthalmology and Therapy
Introduction This study aimed to assess the morphological and functional effects of faricimab in patients with chronic diabetic macular edema (DME) who had an insufficient response to previous treatments.
Viktoria Deiters, Anna Lorger, Franziska Eckardt, Jakob Siedlecki, Benedikt Schworm, Siegfried G. Priglinger, Tina R. Herold   +6 more
doaj   +1 more source

Peptide‐Bound Aflibercept Eye Drops for Treatment of Neovascular Age‐Related Macular Degeneration in Nonhuman Primates

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This article demonstrates that the peptide bxyPenetratin (bxyWP) non‐covalently binds to the anti‐vascular endothelial growth factor (VEGF) protein aflibercept via hydrophobic interactions, enabling noninvasive delivery of aflibercept to the choroid and retina through conjunctival‐scleral pathway and effective inhibition of choroidal neovascularization
Xingyan Fan, Kuan Jiang, Yongqian Zhao, Benjamin TK Lee, Feiyang Geng, Marten E Brelen, Weiyue Lu, Gang Wei   +7 more
wiley   +1 more source

The HAT Inhibitor ISOX‐DUAL Diminishes Ischemic Areas in a Mouse Model of Oxygen‐Induced Retinopathy

Genes to Cells, Volume 30, Issue 2, March 2025.
ISOX DUAL was intraperitoneally administered to OIR mice for 5 days starting from P12, and retinas were excised at P17 to create flat mounts. The percentage of ischemic and neovascular areas relative to the total area was calculated, and a decrease in ischemic and neovascular areas was observed following ISOX DUAL administration (b) compared with ...
Kengo Nakanishi, Yoshihiro Takamura, Yusei Nakano, Masaru Inatani, Masaya Oki   +4 more
wiley   +1 more source

Summary of Research: Cost‑Effectiveness of Faricimab in the Treatment of Diabetic Macular Oedema (DMO): A UK Analysis

Ophthalmology and Therapy
This is a summary of the original article ‟Cost‑Effectiveness of Faricimab in the Treatment of Diabetic Macular Oedema (DMO): A UK Analysis”. DMO, a serious eye condition that can lead to vision loss in people with diabetes, is a significant health ...
Christian Bührer, Thomas Paling, Richard Gale, Tatiana Paulo, Marloes Bagijn   +4 more
doaj   +1 more source

Sequence and Configuration of a Novel Bispecific Antibody Format Impacts Its Production Using Chinese Hamster Ovary (CHO) Cells

Biotechnology and Bioengineering, Volume 122, Issue 2, Page 435-444, February 2025.
Bispecific BYbe® format sequence and configuration impacts secretory titre. Variable fragment (Fv) sequence and placement can reduce or enhance titre. Vector development strategies that allow tuning and rapid assessment of the ratios of transcripts and polypeptides of different chains in bispecific molecules will facilitate optimisation of vector ...
Hirra Hussain, Angelica M. S. Ozanne, Tulshi Patel, Davide Vito, Mark Ellis, Matthew Hinchliffe, David P. Humphreys, Paul E. Stephens, Bernie Sweeney, James White, Alan J. Dickson, C. Mark Smales   +11 more
wiley   +1 more source

Faricimab versus bevacizumab for neovascular age‐related macular degeneration: Cost analysis based on real‐world data from the Swedish Macula Registry

Acta Ophthalmologica, Volume 103, Issue 1, Page 99-108, February 2025.
Abstract Purpose To analyse the impact on cost if faricimab is used as the first‐line treatment for neovascular age‐related macular degeneration (nAMD) compared to standard treatment with bevacizumab. Methods Retrospective registry study including real‐world data from the Swedish Macula Registry between 2017 and 2022.
Souad Abdalla, Inger Westborg, Anni‐Maria Pulkki‐Brännström, Helena Norberg   +3 more
wiley   +1 more source