Results 61 to 70 of about 50,623 (163)

Signal transduction mechanism of biased ligands at histamine H2 receptors [PDF]

open access: yes, 2014
7TMRs (seven-transmembrane receptors) exist as conformational collections in which different conformations would lead to differential downstream behaviours such as receptor phosphorylation, G-protein activation and receptor internalization.
Alonso, Natalia   +5 more
core   +1 more source

Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE [PDF]

open access: yes, 2014
Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC.
Delfino, Mario Raul   +3 more
core   +1 more source

A Standardized Unpredictable Chronic Stress Protocol for Adult Zebrafish

open access: yesCurrent Protocols, Volume 6, Issue 4, April 2026.
Abstract The unpredictable chronic stress (UCS) protocol, originating in the 1980s, has contributed to depression research by inducing behavioral and physiological changes in rodents that resemble the symptoms observed in patients. Its translational potential led to widespread adoption, but adaptations and variations to the protocol have raised ...
Matheus Gallas‐Lopes   +2 more
wiley   +1 more source

EPIDEMIOLOGÍA DEL USO DE MEDICAMENTOS EN EL ADULTO MAYOR

open access: yesRevista Médica Clínica Las Condes, 2016
Los adultos mayores son importantes consumidores de fármacos. Un tercio de las prescripciones de medicamentos son hechas en esta población. Revisiones sistemáticas de la literatura han demostrado una importante relación entre el uso de medicamentos y un ...
Dr. Felipe Salech, PhD   +2 more
doaj   +1 more source

Optogenética: una haz de luz para conocer las funciones cerebrales [PDF]

open access: yes, 2017
Una de las grandes preguntas que nos hacemos en neurociencia es cómo la actividad neuronal crea diversas funciones en el cerebro, resultando en un determinado comportamiento. Para poder analizar esta pregunta, nos vemos obligados a analizar lo que ocurre
Blake, Mariano Guillermo   +3 more
core  

Chia Oil Supplementation Attenuates Obesity‐Induced Hepatic Steatosis, PVAT Inflammation, and Endothelial Dysfunction in Mice

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
We studied whether chia oil, rich in healthy omega‐3 fats, could improve health in obese mice. The oil reduced fat accumulation in the liver, decreased inflammation around blood vessels, and helped blood vessels relax better. These results suggest chia oil may help prevent complications of obesity, like fatty liver and heart disease.
Agatha de Assis‐Ferreira   +10 more
wiley   +1 more source

Farmacología de los azoles [PDF]

open access: yes, 2007
Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake.
Azanza, J.R. (José Ramón)   +2 more
core  

An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction‐Associated Steatotic Liver Disease Progression and in Drug‐Induced Liver Injury

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
Fecal extracellular vesicles (fEVs) from DILI patients have a distinct bacterial profile. This study provides evidence that bacterial EVs enter the bloodstream. DILI and MASLD F≥3 fEVs increase the pro‐inflammatory response and hepatocyte steatosis. FEVs from DILI patients enhance the hepatotoxic potential of diclofenac.
Antonio J. Ruiz‐Malagón   +16 more
wiley   +1 more source

Methodological proposal with an interdisciplinary approach for teaching learning content theory of the pharmacological receptor in the medical career

open access: yesMedisur, 2021
Background: in therapeutic decision-making, the importance of knowledge of the drug receptor theory content is recognized; however, there is a lack of proposals from interdisciplinarity, which is useful as reference for teachers to improve the teaching ...
Yeny Dueñas Pérez   +5 more
doaj  

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