Results 31 to 40 of about 9,289 (170)

Cross‐Talk Between Histamine H2 Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)‐mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific agonist, amthamine, enhances GR transcriptional ...
Valeria Torralba‐Agu, Natalia Fernández, Carina Shayo, Carlos Davio, C. Daniel Zappia, Federico Monczor   +5 more
wiley   +1 more source

Possibilidades terapêuticas e risco toxicológico de Jatropha gossypiifolia L.: uma revisão narrativa Therapeutic possibilities and toxicological risk of Jatropha gossypiifolia L.: a narrative review

Revista Brasileira de Plantas Medicinais, 2010
A espécie Jatropha gossypiifolia L. (Euphorbiaceae), popularmente conhecida como pião-roxo, entre tantos outros nomes, é um bom exemplo do tênue limiar que separa o efeito terapêutico do tóxico.
S.R. Mariz, A.C.R. Borges, M.F.F. Melo-Diniz, I.A. Medeiros   +3 more
doaj   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, Volume 41, Issue 10, Page 957-974, October 2026.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Farmacodermia em cão da raça Dálmata: Relato de caso

Pubvet, 2018
Entende-se como farmacodermia a reação de hipersensibilidade a determinados fármacos manifestada por lesões dermatológicas focais ou difusas. Este trabalho apresenta um caso de farmacodermia em cão após administração de amoxicilina associada a ...
Claudio Douglas de Oliveira Guimarães, Caio Vitor Cavalcante de Carvalho, Ene Madeira de Oliveira Aires, Mário José Costa Carneiro, Maridelzira Betânia Moraes David, Luiz Fernando Moraes Moreira   +5 more
doaj   +1 more source

Revisiting the Association of Pesticide Exposure and Parkinson's Disease: Systematic Review and Meta‐Analysis

Environmental Toxicology, Volume 41, Issue 10, Page 875-888, October 2026.
ABSTRACT The association between pesticide exposure and Parkinson's disease (PD) is substantial, but heterogeneity in methodology and lack of categorization according to the type of exposure and pesticide classes in previous meta‐analyses impair the interpretation of data. This study aims to update evidence of the association between pesticide exposure
Pedro Henrique Passos da Silva, Jadson Silva Abreu, Rafael Sidônio Gibson Gomes, Hemengella Karyne Alves Oliveira, Artur F. S. Schuh, Ignacio F. Mata, Bruno Lopes Santos‐Lobato   +6 more
wiley   +1 more source

Alguns aspectos do uso do hipoclorito de sódio em endodontia

Revista da Faculdade de Odontologia de Porto Alegre, 1991
Os autores estudaram soluções de NaOCI de uso endodôntico, em diferentes concentrações de cloro, buscando esclarecer os seguintes tópicos: a) Velocidade de "envelhecimento" (perda do teor de cloro) nas diferentes concentrações - 5%, 2,5% - 1% - 0,5 ...
Nicolau F. Milano, Vera Girardi, Ana Maria Bergold, Lea Gusmão Chiapini   +3 more
doaj   +1 more source

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

Aging Cell, Volume 25, Issue 10, October 2026.
Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Eva Tudurí, Lucía Almagro, Ana Ojeda‐Rodríguez, Raquel Pascua‐Maestro, Henver S. Brunetta, Sergi Soriano, Alejandro López‐Moreno, Talía Boronat‐Belda, Sergio Velasco‐Avilés, Joel Alves da Silva Junior, Manuel Castellano‐Muñoz, Alex Rafacho, Irene Cózar‐Castellano, Ángel Nadal, Paloma Alonso‐Magdalena, Beatriz Merino, José López‐Miranda, Ivan Quesada   +17 more
wiley   +1 more source

Inibição seletiva da ciclo-oxigenase-2: riscos e benefícios Selective inhibition of cyclooxygenase-2: risks and benefits

Revista Brasileira de Reumatologia, 2012
Os anti-inflamatórios inibidores das ciclo-oxigenases (COX) representam a classe de fármacos mais comumente utilizada. A COX corresponde a uma classe de enzimas conservadas evolutivamente e tem duas isoformas principais: a COX-1 e a COX-2.
Reila Tainá Mendes, Cassiano Pereira Stanczyk, Regina Sordi, Michel Fleith Otuki, Fábio André dos Santos, Daniel Fernandes   +5 more
doaj   +1 more source

Evaluating Leadership and Teamwork Competency Acquisition Through Clinical Simulation: Development of the Clinical Simulation Learning Leadership and Teamwork Scale

Journal of Clinical Nursing, Volume 35, Issue 10, Page 4285-4294, October 2026.
ABSTRACT Advanced simulation is a methodology that allows the development of technical skills and transversal skills such as teamwork and leadership. There are tools to measure the development of technical competencies and student satisfaction with the methodology, but not to measure the development and use of transversal competencies in the clinical ...
Rafael González‐Moret, Beatriz Rodríguez Díez‐Caballero, Manuel Romero‐Saldaña, Daniel García‐Gutiérrez, Cristina García‐Salido, Estel·la Ramírez‐Baraldes, Isabel Serra Guillén   +6 more
wiley   +1 more source

Tailored Diketopyrrolopyrrole Derivatives for Efficient Deep‐Red Organic Lasers

Advanced Functional Materials, Volume 36, Issue 72, 7 September 2026.
Tailored diketopyrrolopyrrole derivatives exhibit high stable amplified spontaneous emission with single or dual bands. Incorporated into distributed‐feedback lasers based on one‐ and two‐dimensional dichromated‐gelatin diffractive gratings, these materials provide a robust, flexible platform for integrated organic deep‐red light sources. ABSTRACT Deep‐
Pablo Pasqués‐Gramage, Abelardo Sánchez‐Oliva, Álex Farrando‐Pérez, Pedro G. Boj, M. Victoria Gómez, Ana M. Rodríguez, Pilar Prieto, Rafael Muñoz‐Mármol, Andrew J. Musser, Iván Torres‐Moya, María A. Díaz‐García   +10 more
wiley   +1 more source