Results 1 to 10 of about 63 (58)
Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2021 The enzymes of the cytochrome P450 superfamily play a critical role in phase I drug metabolism. Among them, CYP2C9 and CYP2C19 are clinically important, as they can mediate severe toxicity, therapy failure, and increased susceptibility to cancer and ...
Vidović Stojko +6 more
doaj +2 more sources
Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2021 Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of ...
Božina Nada +9 more
doaj +2 more sources
UGT2B7 c.-161C>T polymorphism frequency in Croatian population [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2022 Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain.
Božina Tamara +6 more
doaj +2 more sources
Farmakogenetika antidepresivov
Zdravniški Vestnik, 2007 Izhodišča: Pri zdravljenju z antidepresivi velik problem predstavlja neodzivnost na zdravljenje, ki je ni mogoče vnaprej napovedati, pojavi pa se kar pri tretjini bolnikov.
Alessandro Serretti, Paolo Olgiati
doaj +1 more source
Precizna medicina u neuropedijatriji
Liječnički vjesnik, 2023 Uvod: Precizna medicina obuhvaća metode liječenja usmjerene prema potrebama individualnog bolesnika na osnovi genskih karakteristika, biomarkera, fenotipa ili psihosocijalnih karakteristika uz prilagođavanje medicinskih postupaka individualnim ...
Maša Malenica
doaj +1 more source
Farmakogenetski označevalci v terapiji akutne limfoblastne levkemije pri otrocih
Zdravniški Vestnik, 2019 Posamezniku prilagojeno zdravljenje predstavlja sodoben koncept v medicinski praksi, ki temelji na spoznanju, da se posamezniki različno odzivajo na določeno terapijo.
Alenka Šmid +2 more
doaj +1 more source
Zdravniški Vestnik, 2014 Introduction Increased serum level of low density lipoprotein (LDL) cholesterol is a well established risk factor for atherosclerosis development and progression.
Jovana Nikolajević-Starčević +8 more
doaj
, 2023 Pharmacogenetics is a discipline that deals with determining person's genetic profile and tries to predict best drug in the optimal dose. Antidepressants are one of the most important drugs that are highly influenced by genetic polymorphisms in genes that are encoding for enzymes involved in their metabolism (CYP2D6 and CYP2C19 mostly).
openaire +1 more source
Medicus, 2004 Pharmacogenetics, and particularly pharmacogenomics, are new scientific disciplines whose initial results hold promise that the homogeneous groups with respect to the expected therapeutic response will be recognized among people suffering from depression, which would enable its more efficient treatment.
Henigsberg, Neven +1 more
openaire +2 more sources
The Pharmacogenetics of Cardiovascular Drugs / FARMAKOGENETIKA KARDIOVASKULARNIH LEKOVA
Journal of Medical Biochemistry, 2014 Summary This article will primarily summarize the current knowledge of the pharmacogenetics of commonly used drugs for the cardiovascular system: oral anticoagulants, antiplatelet therapy and statins. Coumarin anticoagulants are widely used to treat and prevent thromboembolisms.
Sanja Stanković +2 more
openaire +1 more source