Results 11 to 20 of about 63 (58)

Farmakogenetika inhibitora protonske pumpe

, 2022
Cilj istraživanja: Cilj ovog rada je utvrditi utjecaj genetičkog polimorfizma CYP2C19 na farmakokinetiku inhibitora protonske pumpe (IPP) te prikazati utjecaj različitih varijanti ovog gena na ishode liječenja. Materijali i metode: Pretraživanjem znanstvene literature detaljno je opisan utjecaj polimorfizma CYP2C19 na IPP-e i ishode liječenja ovisno o ...
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Farmakogenetika rosuvastatina

, 2014
Atherosclerosis is a disease in the main of the most cardiovascular disease. It is a result of many factors, one of the major is dyslipidemia, which leading to damages and changes in arterial endothelial function. Treatment aims are to slow the progression or to regression of the disease.
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Farmakogenetika klopidogrela

, 2018
Objectives: The goal of this thesis is to give an overview on the genetic factors that can affect the efficiency and safety of clopidogrel therapy for the purpose of improving pharmacists counseling and therapy individualization. Materials and methods: To that end, scientific literature, therapy guidelines and publications from relevant organizations ...
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Pharmacogenetics may Influence Tacrolimus Daily Dose, but not Urinary Tubular Damage Markers in the Long-Term Period after Renal Transplantation. [PDF]

J Med Biochem, 2015
Stefanović NZ, Cvetković TP, Veličković-Radovanović RM, Jevtović-Stoimenov TM, Vlahović PM, Stojanović IR, Pavlović DD.   +6 more
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Farmakogenetika tiopurinskih lijekova

, 2015
Tiopurinski lijekovi azatioprin (AZA), 6-merkaptopurin (6-MP) i 6-tiogvanin (6-TG) primjenjuju se za liječenje malignih bolesti, reumatskih bolesti, dermatoloških stanja, upalnih bolesti crijeva i nekih poremećaja imunološkog sustava. Aktivni metaboliti tiopurina djeluju kao purinski antagonisti i inhibiraju sintezu endogenih purina, DNA, RNA i nekih ...
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Farmakogenetika varfarina u kliničkoj praksi

Biochemia Medica, 2010
Warfarin is the most widely prescribed oral anticoagulant. It shows great (up to 20-fold) interindividual variability in dose requirement because of both, genetic and environmental factors. Information from pharmacogenomics, a study of the interaction of the individual's genotype and drug response, can help optimize drug efficacy and minimize adverse ...
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Farmakogenetika tiopurin-S-metiltransferaze

, 2008
Pharmacogenetics studies the genetic basis of inter-individual differences in drug response. The goal of pharmacogenetic testing is to individualize drug treatment by identifying relevant factors which influence drug efficacy and lower the therapy-related toxicity in individual patients.
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Rare variants in cholesterol transporter genes in patients with lipid metabolism disorders. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Izyumchenko AD, Grunina MN, Dracheva KV, Chumakova OA, Tanayants KO, Legostaeva KV, Kulikov AN, Berkovich OA, Baranova EI, Pchelina SN, Miroshnikova VV.   +10 more
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Can pharmacogenetics impact the therapeutic effect of cytarabine and anthracyclines in adult acute myeloid leukaemia patients?: A Serbian experience. [PDF]

J Med Biochem
Pravdić Z, Suvajdžić-Vuković N, Virijević M, Mitrović M, Pantić N, Sabljić N, Pavlović Đ, Marjanović I, Bukumirić Z, Vidović A, Jaković L, Pavlović S, Gašić V.   +12 more
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Farmakogenetika i interakcije direktnih oralnih antikoagulantnih lijekova

, 2022
Direktni oralni antikoagulansi (DOAK) posljednjih su godina pokazali rastući trend propisivanja zbog povoljne farmakokinetike i farmakodinamike bez potrebe za rutinskim nadzorom koagulacije. Svoj antikoagulantni učinak ostvaruju izravnom inhibicijom trombina (dabigatran) ili izravnom inhibicijom aktiviranog čimbenika X (rivaroksaban, apiksaban i ...
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