Mechanism of Catalysis and Inhibition of Mammalian Protein Farnesyltransferase. [PDF]
, 2007 Mammalian protein farnesyltransferase (FTase) catalyzes the transfer of a 15-carbon prenyl group from farnesyl diphosphate (FPP) to a cysteine residue near the carboxyl terminus of many proteins, including several key molecules involved in signal ...
Pais, June E.
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Molecular Recognition of Substrates by Protein Farnesyltransferase and Geranylgeranyltransferase-I. [PDF]
Prenylation is an important post-translational modification that targets proteins to the cellular membrane. Farnesyltransferase (FTase) catalyzes the attachment of the 15-carbon farnesyl moiety from farnesyldiphosphate to a cysteine near the C-terminus ...
Lamphear, Corissa L.
core
Pre-loading of chlorophyll synthase with tetraprenyl diphosphate is an obligatory step in chlorophyll biosynthesis [PDF]
, 2002 Oster, Ulrike +4 more
core +1 more source
Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases [PDF]
, 2012 core +1 more source
Farnesyltransferase Inhibitor in Cancer Treatment [PDF]
, 2011 Anuj G. Agrawal, Rakesh R. Somani
core +2 more sources
Entwicklung neuer Deskriptoren für vergleichende molekulare Feldanalysen und Verfahren zur Beschreibung der Selektivität von Serinproteasen [PDF]
, 2002 Böhm, Markus, Prof. Dr. G. KLEBE
core +1 more source
Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from <i>Syzygium cumini</i> essential oils. [PDF]
Mol Biol Res CommunPutra WE +5 more
europepmc +1 more source
Cancer Therapy Utilizing the RAS Protein Family [PDF]
The RAS protein family functions as binary switch proteins toggling between active (GTP-bound) and inactive (GDP-bound) states, regulating pivotal cellular pathways like PI3K, MAPK, and Ral-GEF.
Ha, Brandon +5 more
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Farnesyltransferase inhibitors decrease matrix-vesicle-mediated mineralization in SaOS-2 cells. [PDF]
Mol Biol RepBürgel T +5 more
europepmc +1 more source
Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification. [PDF]
Int J Mol SciChevalier Q +3 more
europepmc +1 more source