Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis [PDF]
Advanced ScienceTargeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial.
Zhen-Ru Wu, Guo-Chao Zhong, Jiejun Hu
exaly +3 more sources
FDFT1 maintains glioblastoma stem cells through activation of the Akt pathway [PDF]
Stem Cell Research and TherapyBackground Cancer stem cells (CSCs) have unique metabolic characteristics and are hypothesized to contribute significantly to the recurrence and drug resistance of glioblastoma multiforme (GBM).
Jianwei Liao, Huang Yongsheng
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Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC
Cancer Medicine, 2022 Renal cell carcinoma (RCC) seriously threatens people's lives and health. The identification of some precise biomarkers during the process of RCC progression and the pathophysiologic procedure is critical for improving the diagnosis and management of RCC.
Honglin Hu, Ruizhen Huang
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Cholesterol synthases suppress metastasis and stemness through PDIA4/ACLY or SYVN1/SCD1 axis in advanced colorectal cancer [PDF]
Communications BiologyAberrant cholesterol biosynthesis is a notable hallmark of cancers, supporting unlimited cell proliferation. Previously, we delineated that cholesterol synthases FDFT1 and SQLE promoted colorectal cancer (CRC) cell proliferation, while how these enzymes ...
Wenjie Li +5 more
doaj +2 more sources
Follicle stimulating hormone stimulates farnesyl-diphosphate farnesyltransferase 1 expression through LSD1Ser54p in chicken ovarian granulosa cells [PDF]
Poultry ScienceOvarian follicular development in laying hens is tightly regulated by a variety of endocrine and cellular factors, among which follicle-stimulating hormone (FSH) plays a decisive role.
Yanhong Zhang +3 more
doaj +2 more sources
Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms [PDF]
Advanced SciencePeripheral nerve myelin is the most cholesterol‐rich structure in the body, with the majority of cholesterol being synthesized by Schwann Cells (SCs). Following peripheral nerve injury, myelin disintegration leads to substantial cholesterol release and ...
Shuyi Xu +12 more
doaj +2 more sources
Cancer Treatment and Research Communications, 2022 According to previous reports,10–16% of patients with clinically advanced cholangiocarcinoma develop FGFR2 fusions or rearrangements. Treatment with FGFR2-specific inhibitors (tyrosine kinase inhibitors, TKIs) has proven effective for patients with ...
Jianping Xiong +2 more
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Cellular and Molecular Biology Letters, 2022 Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates.
Siti Fairus Abdul Sani +2 more
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Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation [PDF]
Cell Communication and SignalingBackground Intrahepatic Cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options. Identifying novel therapeutic agents for ICC is crucial.
Fengyun Zhao +8 more
doaj +2 more sources
Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1 [PDF]
Frontiers in PharmacologyIntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang +6 more
doaj +2 more sources