Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments [PDF]
Cells, 2020 Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Chang Hoon Lee
exaly +7 more sources
Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis [PDF]
Cancer Cell International, 2021 Background Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target
Ruiyang Zhao +7 more
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Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer [PDF]
International Journal of Genomics, 2018 Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors.
Mehdi Dehghani +6 more
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Follicle stimulating hormone stimulates farnesyl-diphosphate farnesyltransferase 1 expression through LSD1Ser54p in chicken ovarian granulosa cells [PDF]
Poultry ScienceOvarian follicular development in laying hens is tightly regulated by a variety of endocrine and cellular factors, among which follicle-stimulating hormone (FSH) plays a decisive role.
Yanhong Zhang +3 more
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Di-san junyi daxue xuebao, 2021 Objective To investigate the effects of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) on the growth of colorectal cancer (CRC) cell line MC-38 in vitro and in mouse models of colorectal peritoneal metastasis and xenograft tumor.
LUO Na +4 more
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A fungal endophyte of the medicinal plant, Alisma orientale, promotes plant growth and bioactive compound accumulation [PDF]
Frontiers in MicrobiologyIntroductionThe Asian water plantain, Alisma orientale (Sam.) Juzep, is a flowering hydrophytic plant that grows in marshes. In traditional Chinese medicine, the rhizome of A. orientale is highly valued for its medicinal properties.
Xiaomei Xu +10 more
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Farnesyl‐diphosphate farnesyltransferase 1 regulates hepatitis C virus propagation
FEBS Letters, 2014 To identify the novel genes involved in lipid metabolism and lipid droplet formation that may play important roles in Hepatitis C virus (HCV) propagation, we have screened the small interfering RNA library using cell culture derived HCV (HCVcc)‐infected cells.
Eun-Mee Park +2 more
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Squalene synthase induces ERα expression via cholesterol supplementation to confer statin resistance in lung cancer cells [PDF]
Cancer Cell InternationalBackground Sterol regulatory element-binding proteins (SREBPs) are master regulators of cholesterol and lipid biosynthesis - pathways increasingly linked to cancer progression.
Yi-Fang Yang +7 more
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Biochemical and Biophysical Research CommunicationsCancer poses a significant risk to human well-being. Among the crucial characteristics of cancer is metabolic reprogramming. To meet the relentless metabolic needs, cancer cells enhance cholesterol metabolism within the adverse tumor microenvironment.
Guojuan Wang, Nanxin Li
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Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells [PDF]
iScienceSummary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He +7 more
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