Results 1 to 10 of about 1,729 (103)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments [PDF]

Cells, 2020
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Chang Hoon Lee, Lee Chang Hoon
exaly   +4 more sources

Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis [PDF]

Cancer Cell International, 2021
Background Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target
Ruiyang Zhao, Bo Cao, Hanghang Li, Tian Li, Xingming Xu, Hao Cui, Huan Deng, Bo Wei   +7 more
doaj   +2 more sources

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer [PDF]

International Journal of Genomics, 2018
Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors.
Mehdi Dehghani, Zahra Samani, Hassan Abidi, Leila Manzouri, Reza Mahmoudi, Saeed Hosseini Teshnizi, Mohsen Nikseresht   +6 more
doaj   +2 more sources

Follicle stimulating hormone stimulates farnesyl-diphosphate farnesyltransferase 1 expression through LSD1Ser54p in chicken ovarian granulosa cells [PDF]

Poultry Science
Ovarian follicular development in laying hens is tightly regulated by a variety of endocrine and cellular factors, among which follicle-stimulating hormone (FSH) plays a decisive role.
Yanhong Zhang, Min Zhang, Qingxin Liu, Yunliang Jiang   +3 more
doaj   +2 more sources

A fungal endophyte of the medicinal plant, Alisma orientale, promotes plant growth and bioactive compound accumulation [PDF]

Frontiers in Microbiology
IntroductionThe Asian water plantain, Alisma orientale (Sam.) Juzep, is a flowering hydrophytic plant that grows in marshes. In traditional Chinese medicine, the rhizome of A. orientale is highly valued for its medicinal properties.
Xiaomei Xu, Wenjin Lin, Nemat O. Keyhani, Yamin Zhang, Junyong Han, Huiqing Que, Luxiao Wang, Yuhang Yao, Sen Liu, Xiaoyan Chen, Junzhi Qiu   +10 more
doaj   +2 more sources

Squalene synthase induces ERα expression via cholesterol supplementation to confer statin resistance in lung cancer cells [PDF]

Cancer Cell International
Background Sterol regulatory element-binding proteins (SREBPs) are master regulators of cholesterol and lipid biosynthesis - pathways increasingly linked to cancer progression.
Yi-Fang Yang, Yu-Chan Chang, Ming-Hsien Chan, Min-Hsi Lin, Chih-Jen Yang, Ming-Shyan Huang, Yi-Hua Jan, Michael Hsiao   +7 more
doaj   +2 more sources

Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. [PDF]

Food Sci Nutr
Transcriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Visan S, Balacescu L, Drigla F, Balacescu O, Pintea A.   +4 more
europepmc   +2 more sources

Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis

Advanced Science
Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial.
Dong Cai, Guo‐Chao Zhong, Xin Dai, Zhibo Zhao, Menglin Chen, Jiejun Hu, Zhenru Wu, Lve Cheng, Shengwei Li, Jianping Gong   +9 more
doaj   +2 more sources

Examining Farnesyltransferase Interaction With Cell-Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity. [PDF]

J Pept Sci
This work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Klußmann M, Reuter J, Werner C, Neundorf I.   +3 more
europepmc   +2 more sources

Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus [PDF]

Diabetes, Metabolic Syndrome and Obesity
Jin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of ...
Zhao JD, Fang ZH
doaj   +2 more sources