Results 41 to 50 of about 1,729 (103)

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Crizotinib induces excessive accumulation of squalene epoxidase (SQLE) by blocking its autophagic degradation. This accumulation disrupts cholesterol and sphingolipid metabolism, leading to hepatic steatosis or hepatocyte apoptosis, respectively. Autophagy activators, such as metformin, or SQLE enzymatic inhibitors, like terbinafine, possesses the ...
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
wiley   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1

Frontiers in Pharmacology
IntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang, Jiazhuo Liu, Yisong Yang, Ran Tao, Xin Ren, Xingzhi Zhou, Shuangping Liu   +6 more
doaj   +1 more source

Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from <i>Syzygium cumini</i> essential oils. [PDF]

Mol Biol Res Commun
Putra WE, Hidayatullah A, Widiastuti D, Isnanto H, Heikal MF, Sustiprijatno.   +5 more
europepmc   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S-Prenylation to Tryptophan-Selective Biocatalysis. [PDF]

Chemistry
Fujinami D, Ozawa H, Ito S.
europepmc   +1 more source

L-Theanine ameliorates high-protein diet-associated hepatic glucose and lipid metabolic alterations by promoting fatty acid β-oxidation and suppressing lipid synthesis and gluconeogenesis in rats. [PDF]

Curr Res Food Sci
Liu S, Li L, Yao K, He L, Yuan Y, Tan Y, Yin F, Gong Z, Xiao W.   +8 more
europepmc   +1 more source

<i>Ganoderma lucidum</i> polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice. [PDF]

Int J Mol Med
Jin X, Liu X, Wang YJ, Lei ZL, Yang YH.
europepmc   +1 more source

Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth. [PDF]

Nat Commun
Miao T, Liu Y, Qadiri M, Dasseux A, Asara JM, Hu Y, Sun X, Pliego-Alcántara LDC, Dibble CC, Perrimon N.   +9 more
europepmc   +1 more source

Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution. [PDF]

ACS Chem Biol
Coca-Ruiz V, Hausmann K, Dräger G, Struwe H, Zahid M, Aleu J, Solle D, Kirschning A, Collado IG, Beutel S.   +9 more
europepmc   +1 more source

Farnesyltransferase inhibitors decrease matrix-vesicle-mediated mineralization in SaOS-2 cells. [PDF]

Mol Biol Rep
Bürgel T, Diehl D, van Lier EC, Friedmann A, Hagemann A, Bachmann HS.   +5 more
europepmc   +1 more source