Results 21 to 30 of about 2,791 (152)

RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Nature Communications, 2020
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao   +15 more
doaj   +1 more source

Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes† [PDF]

, 2018
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition.
Amos, Ayres, Bergstrom, Bergstrom, Bicalho, Billington, Bloch, Bonnett, Bustin, Christian, Cronin, Forman, Fukuchi, Gan, Gareth D Healey, Goldstein, Goldstein, Gonzalez, Griffin, Gurcel, Hardie, Healy, Hiyoshi, Huffman, I Martin Sheldon, Jost, Kalaany, Karstrup, Keller, Lange, LeBlanc, LeBlanc, Liao, Maxfield, McCusker, Mihaylova, Moore, Morgan, Mosmann, Park, Peraro, Preta, Preta, Read, Repa, Schneider, Sharpe, Sheldon, Sheldon, Sholeem Griffin, Statt, Turner, Turner, Tweten, Vander Heiden, Wang, Wathes, Westermann, Zoncu, Zwald   +59 more
core   +1 more source

Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells [PDF]

, 2017
Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice.
Abdullah, MI, Abed, MN, Richardson, A
core   +1 more source

Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. [PDF]

, 2004
Background & aimsPathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. In order to investigate the patterns of chromosomal aberrations in gastric carcinomas, we performed
Albertson, Donna, Kuipers, Ernst J, Meijer, Gerrit A, Meuwissen, Stefan GM, Pinkel, Daniel, Postma, Cindy, Snijders, Antoine M, Weiss, Marjan M   +7 more
core   +3 more sources

Isoprenoid Biosynthesis in Plasmodium falciparum [PDF]

, 2014
Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies.
Amthor, Rachel E, Guggisberg, Ann M, Odom, Audrey R   +2 more
core   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Additional file 4 of Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis

, 2021
Additional file 4: Table S1. The sequences of oligo dT and primers used in this study.
Zhao, Ruiyang, Cao, Bo, Li, Hanghang, Li, Tian, Xu, Xingming, Cui, Hao, Deng, Huan, Wei, Bo   +7 more
openaire   +1 more source

Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats

Frontiers in Molecular Neuroscience, 2018
Alcohol use disorder (AUD) is associated with persistent adaptations in the brain that are believed to participate in the long-lasting vulnerability to relapse after abstinence.
Josette Alsebaaly, Josette Alsebaaly, Emilie Dugast, Emilie Dugast, Laure Favot, Lydia Rabbaa Khabbaz, Marcello Solinas, Nathalie Thiriet   +7 more
doaj   +1 more source

Hepatitis C virus genotypes 1–3 infections regulate lipogenic signaling and suppress cholesterol biosynthesis in hepatocytes

Journal of the Formosan Medical Association, 2020
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis C ...
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao   +8 more
doaj   +1 more source

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin [PDF]

, 2017
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens.
A Baxter, A Bellier, A Das, AE Christian, AF Read, B Page, BH Jost, BN Bonnett, CY Kao, DL Huffman, DO Ballard, DS Schneider, EP Kilsdonk, G Krikun, G Preta, GD Healey, IM Sheldon, IM Sheldon, JD Bergstrom, JG Cronin, JL Goldstein, JL Goldstein, JM Park, JW Rosch, K Bloch, KS Giddings, L Gurcel, L Pokrajac, L Raberg, LJ Bischof, LJ Sharpe, MD Peraro, MJ Rogers, ML Turner, MLS Bicalho, MR Amos, MR Gonzalez, R Medzhitov, RK Tweten, S Statt, S Westermann, SA Bustin, SJ Billington, SJ Billington, SJ Billington, T Mosmann, Y Lange   +46 more
core   +2 more sources