Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]
, 2011 The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi +2 more
core +3 more sources
Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]
, 2001 The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia +4 more
core +1 more source
Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer. [PDF]
, 2012 PURPOSE: The Radiation Therapy Oncology Group (RTOG) multi-institutional Phase II study 98-12, evaluating paclitaxel and concurrent radiation (RT) for locally advanced pancreatic cancer, demonstrated a median survival of 11.3 months and a 1-year survival
Anne, Pramila R +9 more
core +1 more source
Animals, 2018 Grape pomace (GPO), the main by-product of the wine making process, is a rich source of polyphenols with potent antioxidant properties. Recently, GPO has emerged as a potential feed additive in livestock nutrition, with several reports describing its ...
Marco Iannaccone +7 more
doaj +1 more source
synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells [PDF]
, 2006 Introduction Bisphosphonates are mostly used in the treatment of bone metastases. They have been shown to act synergistically with other chemotherapeutic agents. It is not known, however, whether similar synergistic effects exist with radiation on breast
A Ugur Ural +30 more
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Pharmacogenetics of osteoporosis: a pathway analysis of the genetic influence on the effects of antiresorptive drugs [PDF]
, 2022 Osteoporosis is a skeletal disorder defined by a decreased bone mineral density (BMD) and an increased susceptibility to fractures. Bisphosphonates and selective oestrogen receptor modulators (SERM) are among the most widely used drugs. They inhibit bone
Hernández Hernández, José Luis +4 more
core +1 more source
FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression
陆军军医大学学报Objective To screen the targets related to the metabolic enzymes involved in the cholesterol synthesis pathway that inhibits the polarization of macrophages towards M1 phenotype, and verify the intervention effects and underlying mechanisms in ...
GAO Yuan, HUANG Yulan, ZHAO Kun
doaj +1 more source
Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
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, 2008 An abundantly growing body of literature implicates conjugation of SUMO in the regulation of many proteins and processes, yet the regulation of SUMO pathways is poorly understood.
Brian J Wilson
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Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection
mBio, 2017 From various screens, we found that Kaposi’s sarcoma-associated herpesvirus (KSHV) viral microRNAs (miRNAs) target several enzymes in the mevalonate/cholesterol pathway.
Anna K. P. Serquiña +3 more
doaj +1 more source