Results 11 to 20 of about 1,729 (103)

Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study [PDF]

Research Journal of Pharmacognosy, 2023
Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet
Mostafa Rezaei Tavirani, Reza Mohamoud Robati*, Alireza Ahmadzadeh, Mohammad Rostami Nejad   +3 more
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Farnesyl-diphosphate farnesyltransferase 1 promotes growth of colorectal cancer cells with dependence on tumor immune microenvironment

Di-san junyi daxue xuebao, 2021
Objective To investigate the effects of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) on the growth of colorectal cancer (CRC) cell line MC-38 in vitro and in mouse models of colorectal peritoneal metastasis and xenograft tumor.
LUO Na, LUO Na, ZHANG Dapeng, MIAO Hongming, DAI Rongyang   +4 more
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Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Communications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun, Diming Liu, Weiwei Cui, Huimin Cheng, Lixia Huang, Ruihao Zhang, Junlian Gu, Shuo Liu, Xiao Zhuang, Yi Lu, Bo Chu, Jian Li   +11 more
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RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Nature Communications, 2020
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao   +15 more
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Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review

Cellular & Molecular Biology Letters, 2022
Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates.
M. Kanmalar, Siti Fairus Abdul Sani, Nur Izzahtul Nabilla B. Kamri, Nur Akmarina B. M. Said, Amirah Hajirah B. A. Jamil, S. Kuppusamy, K. S. Mun, D. A. Bradley   +7 more
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Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats

Frontiers in Molecular Neuroscience, 2018
Alcohol use disorder (AUD) is associated with persistent adaptations in the brain that are believed to participate in the long-lasting vulnerability to relapse after abstinence.
Josette Alsebaaly, Josette Alsebaaly, Emilie Dugast, Emilie Dugast, Laure Favot, Lydia Rabbaa Khabbaz, Marcello Solinas, Nathalie Thiriet   +7 more
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Hepatitis C virus genotypes 1–3 infections regulate lipogenic signaling and suppress cholesterol biosynthesis in hepatocytes

Journal of the Formosan Medical Association, 2020
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis C ...
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao   +8 more
doaj   +1 more source

RNA Sequencing-Based Whole-Transcriptome Analysis of Friesian Cattle Fed with Grape Pomace-Supplemented Diet

Animals, 2018
Grape pomace (GPO), the main by-product of the wine making process, is a rich source of polyphenols with potent antioxidant properties. Recently, GPO has emerged as a potential feed additive in livestock nutrition, with several reports describing its ...
Marco Iannaccone, Ramy Elgendy, Mery Giantin, Camillo Martino, Daniele Giansante, Andrea Ianni, Mauro Dacasto, Giuseppe Martino   +7 more
doaj   +1 more source

Early-onset generalized linear porokeratosis with cutaneous squamous cell carcinomas: A case report and genomic analysis

Dermatologica Sinica
Previous studies have shown that porokeratosis (PK) arises from mutations in the enzyme-encoding genes – mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase (MVD), farnesyl diphosphate synthase, and farnesyl-diphosphate ...
Yike Huang, Ying Qi, Zhen Tian, Qiaoan Zhang, Ou Fang, Jia Chen, Jing Luan, Caihua Li, Zhengwen Jiang, Lixiong Gu, Xiaodong Chen, Zhenghua Zhang   +11 more
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FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression

陆军军医大学学报
Objective‍　‍To screen the targets related to the metabolic enzymes involved in the cholesterol synthesis pathway that inhibits the polarization of macrophages towards M1 phenotype, and verify the intervention effects and underlying mechanisms in ...
GAO Yuan, HUANG Yulan, ZHAO Kun
doaj   +1 more source