Advanced ScienceTargeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial.
Dong Cai +9 more
doaj +2 more sources
Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus [PDF]
Diabetes, Metabolic Syndrome and ObesityJin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of ...
Zhao JD, Fang ZH
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Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. [PDF]
Food Sci NutrTranscriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Visan S +4 more
europepmc +2 more sources
Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study [PDF]
Research Journal of Pharmacognosy, 2023 Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet
Mostafa Rezaei Tavirani +3 more
doaj +1 more source
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
Communications Biology, 2023 Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun +11 more
doaj +1 more source
Examining Farnesyltransferase Interaction With Cell-Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity. [PDF]
J Pept SciThis work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Klußmann M +3 more
europepmc +2 more sources
Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells. [PDF]
, 2015 While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we investigated the response to ...
A Aparicio +91 more
core +8 more sources
Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]
, 2011 The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong +7 more
core +2 more sources
Cellular & Molecular Biology Letters, 2022 Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates.
M. Kanmalar +7 more
doaj +1 more source
Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment [PDF]
, 2016 AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase (SQS), as a promising target for treatment of hypercholesterolaemia.
Burzynska, Beata +12 more
core +1 more source