Results 41 to 50 of about 2,439 (113)

WC1/WC2–Sre1 Transcriptional Cascade Controls Predation and Chlamydospore Formation in the Nematode‐Trapping Fungus Arthrobotrys flagrans

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Systematic functional characterization of all eight GATA‐type transcription factors in the nematode‐trapping fungus Arthrobotrys flagrans reveals a novel, light‐independent WC1/WC2–Sre1 transcriptional cascade that orchestrates both trap formation and chlamydospore development, providing actionable targets for engineering superior biocontrol strains ...
Yu Zhang, Jiafang Zuo, Qianfei Shi, Peiji Zhao, Hanbo Zhang, Minghe Mo, Guohong Li   +6 more
wiley   +1 more source

An Improved Genome Assembly of Azadirachta indica A. Juss.

G3: Genes, Genomes, Genetics, 2016
Neem (Azadirachta indica A. Juss.), an evergreen tree of the Meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties.
Neeraja M. Krishnan, Prachi Jain, Saurabh Gupta, Arun K. Hariharan, Binay Panda   +4 more
doaj   +1 more source

A case–control study in Taiwanese cohort and meta-analysis of serum ferritin in pancreatic cancer

Scientific Reports, 2021
Pancreatic cancer is one of the most lethal diseases which lack an early diagnostic marker. We investigated whether serum ferritin (SF) reflects risk for pancreatic cancer and potential genes that may contribute ferritin and pancreatic cancer risks.
Ji Min Park, Chen-Zou Mau, Yang-Ching Chen, Yen-Hao Su, Hsin-An Chen, Shih-Yi Huang, Jung-Su Chang, Ching-Feng Chiu   +7 more
doaj   +1 more source

Genome Sequencing in 19 Families With Bladder Exstrophy and Epispadias Complex Indicates Involvement of the ADGR ‐Gene Family

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1286-1305, June 2026.
ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld, Samara Alm, Jesper Eisfeldt, Jia Cao, Magnus Anderberg, Gillian Barker, Hans Matsson, Gundela Holmdahl, Anna Lindstrand, Kristina Lagerstedt‐Robinson   +9 more
wiley   +1 more source

Alzheimer's disease biological domain sub‐stratification enhances the precision of functional analyses

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The Target Enablement to Accelerate Therapy Development for AD (TREAT‐AD) bioinformatics pipeline employs a rank‐and‐organize strategy. Disease‐associated genes drive enrichment of large AD‐linked endophenotypes. However, these biological areas were too large to promote hypothesis development or target identification.
Gregory A. Cary, Sai Sruthi Amirtha Ganesh, Laura Heath, Karina Leal, Martin Kampmann, Frank M. Longo, Robert R. Butler III, Allan L. Levey, Gregory W. Carter, Jesse Wiley   +9 more
wiley   +1 more source

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Immune and Metabolic Biomarkers in a Rodent Model of Spinal Cord Contusion

Global Spine Journal, 2022
Study Design: Basic science animal research study. Objectives: Using T10 spinal contused rats, we sought to identify molecular and circulating, metabolic and immune biomarkers during the subchronic and chronic recovery periods that may inform us ...
Christiano dos Santos e Santos MD, Bradley A. Welch BS, Shelley R. Edwards MS, Kwamie K. Harris MS, Brittany C. Duncan MS, Alexandra R. Himel MS, Bernadette E. Grayson PhD, MCR   +6 more
doaj   +1 more source

Genome-wide search identified DNA methylation sites that regulate the metabolome

Frontiers in Genetics, 2023
Background: Identifying DNA methylation sites that regulate the metabolome is important for several purposes. In this study, publicly available GWAS data were integrated to find methylation sites that impact metabolome through a discovery and replication
Majid Nikpay
doaj   +1 more source

Highly heterozygous Citrus changshan‐huyou Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue‐specific allelic imbalance

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract The genus Citrus is characterized by a reticulate evolutionary history with frequent hybridization, making it an intriguing subject for genome evolution investigation. Citrus changshan‐huyou Y. B. Chang (Huyou) is a unique landrace first discovered in Zhejiang Province, China, with premium fruit quality.
Zhanghui Zeng, Yingjie Luo, Haifei Hu, Lan Lan, Baojin Guo, Ping Zhou, Cong Tan, Xiaoping Huang, Tuo Qi, Zhehao Chen, Zhiming Yu, Lilin Wang, Taihe Xiang, Chengdao Li, Yong Jia   +14 more
wiley   +1 more source

UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines

Molecular Oncology, 2022
Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three separately established breast EMT ...
Qiong Wang, Sigurdur Trausti Karvelsson, Freyr Johannsson, Arnar Ingi Vilhjalmsson, Lars Hagen, Davi deMiranda Fonseca, Animesh Sharma, Geir Slupphaug, Ottar Rolfsson   +8 more
doaj   +1 more source