Results 41 to 50 of about 3,880 (180)

Transcriptome analysis reveals the effect of grafting on gossypol biosynthesis and gland formation in cotton

BMC Plant Biology, 2023
Background Gossypol is a unique secondary metabolite and sesquiterpene in cotton, which is mainly synthesized in the root system of cotton and exhibits many biological activities.
Kun Ye, Teng Teng, Teng Yang, Degang Zhao, Yichen Zhao   +4 more
doaj   +1 more source

Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]

, 2018
Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia, Morales, Diego, Soler-Rivas, Cristina   +2 more
core   +1 more source

Localization of the Squalene Synthase Gene (FDFT1) to Human Chromosome 8p22-p23.1

Genomics, 1994
Recently, we reported the isolation of a cDNA encoding the human enzyme squalene synthase, the first step of sterol biosynthesis uniquely committed to synthesis of cholesterol (6). As such, it is likely that this enzyme occupies a critical regulatory position in the synthesis of cholesterol.
I, Shechter, D G, Conrad, I, Hart, R C, Berger, T L, McKenzie, J, Bleskan, D, Patterson   +6 more
openaire   +2 more sources

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

Human gene copy number spectra analysis in congenital heart malformations [PDF]

, 2012
The clinical significance of copy number variants (CNVs) in congenital heart disease (CHD) continues to be a challenge. Although CNVs including genes can confer disease risk, relationships between gene dosage and phenotype are still being defined.
Bick, David P., Broeckel, Ulrich, Goetsch, Mary A., Harris, Susan, Hidestrand, Mats, Mahnke, Donna K., Mitchell, Michael, Pelech, Andrew N., Simpson, Pippa, Stamm, Karl D., Struble, Craig, Tomita-Mitchell, Aoy, Tuffnell, Maureen E., Tweddell, James S.   +13 more
core   +2 more sources

STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus

eLife, 2022
Mapping of allelic imbalance (AI) at heterozygous loci has the potential to establish links between genetic risk for disease and biological function. Leveraging multi-omics data for AI analysis and functional annotation, we discovered a novel functional ...
Yanfeng Zhang, Kenneth Day, Devin M Absher   +2 more
doaj   +1 more source

Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study [PDF]

Research Journal of Pharmacognosy, 2023
Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet
Mostafa Rezaei Tavirani, Reza Mohamoud Robati*, Alireza Ahmadzadeh, Mohammad Rostami Nejad   +3 more
doaj   +1 more source

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

International Journal of Genomics, 2018
Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors.
Mehdi Dehghani, Zahra Samani, Hassan Abidi, Leila Manzouri, Reza Mahmoudi, Saeed Hosseini Teshnizi, Mohsen Nikseresht   +6 more
doaj   +1 more source

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo [PDF]

, 2014
Here, we exploit the spatial separation of temporal events of neural differentiation in the elongating chick body axis to provide the first analysis of transcriptome change in progressively more differentiated neural cell populations in vivo.
Abranches, Akai, Altschul, Amijee, Arbeitman, Aubert, Bel-Vialar, Benjamini, Bradford, Brown, Chitnis, Delfino-Machín, Deschamps, Deschenes, Diez del Corral, Diez del Corral, Dittmar, Eblaghie, Fior, Goodwin, Hamburger, Henrique, Irizarry, Jares, Kuhns, Landeira, Lessard, Li, Lobjois, Lunn, Martin, Miettinen, Minowada, Mitiku, Olivera-Martinez, Ozbudak, Ozsolak, Park, Patel, Perry, Rae, Rae, Schurch, Smyth, Smyth, Stavridis, Stern, Storey, Sultan, Tsakiridis, Tzouanacou, van der Vlag, Wilcock, Willnow, Wilson, Wu, Zhang, Zhao   +57 more
core   +5 more sources