Results 61 to 70 of about 2,439 (113)

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, Volume 4, Issue 1, Page 36-54, February 2026.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Survival of adult neurons lacking cholesterol synthesis in vivo

BMC Neuroscience, 2007
Background Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the ...
Möbius Wiebke, Xiao Le, Saher Gesine, Fünfschilling Ursula, Nave Klaus-Armin   +4 more
doaj   +1 more source

Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension

Epigenetics
The complex pathophysiology of essential hypertension (EH) continues to pose challenges to blood control. This study investigated the association of blood DNA methylation and gene expression with EH in blood and arterial tissues to identify potential ...
Xinmeng Hu, Huizhen Jin, Xiaoyang Li, Zhuoshuai Liang, Jikang Shi, Hongrui Zhang, Jiahui Zhao, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu   +10 more
doaj   +1 more source

Integrative analysis of metabolomics and transcriptomics reveals alterations in egg quality and hepatic lipid metabolism in hens supplemented with curcumin

Animal Nutrition
Curcumin has been shown to affect lipid metabolism in various ways, but its molecular mechanisms in hens remain poorly understood. In this study, 378 Hy-Line Brown hens, aged 58 weeks, were randomly assigned into three groups, each consisting of 6 ...
Cunzhi Zou, Haiyu Jiang, Xuanfu Wu, Jiang Gao, Wenqiang Ma   +4 more
doaj   +1 more source

Steroid Biosynthesis Pathway Counteracts Iron Overload-Induced Ferroptosis in Mouse Granulosa Cells

Biology
Iron overload is a recognized risk factor for female reproductive dysfunction, yet the underlying cellular and molecular mechanisms remain incompletely understood.
Feiyan Gao, Weiran Mao, Xiaoying He, Ying Liu, Yang Liu, Shujun Liu, Jiwei Liu, Libing Ma   +7 more
doaj   +1 more source

Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model [PDF]

PeerJ
Backgrounds Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a condition characterized by transient left ventricular dysfunction without coronary artery obstruction. Methods We utilized label-free quantitative proteomics to
Liuyang Tian, Botao Liu, Ying Ren, Jian Cui, Zhihua Pang   +4 more
doaj   +2 more sources

Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development

Advanced Science
Oligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms ...
Wenwen Wang, Yanyan Wang, Libo Su, Mengtian Zhang, Tianyu Zhang, Jinyue Zhao, Hongyan Ma, Dongming Zhang, Fen Ji, Ryan Dingli Jiao, Hong Li, Yuming Xu, Lei Chen, Jianwei Jiao   +13 more
doaj   +1 more source

Integrated metabolomics and proteomics analysis reveals the accumulation mechanism of bioactive components in Polygonatum odoratum

Frontiers in Plant Science
Polygonatum odoratum (Mill.) Druce is rich in bioactive components with high medicinal value. To maximize the clinical benefits, it is of great significance to efficiently extract key bioactive components from appropriate growth stages in which they are ...
Shuang Liang, Yang Zhao, Zhaohui Luo, Junchen Liu, Xicen Jiang, Bingxian Yang, Lin Zhang, Hongwei Fu, Zhuoheng Zhong   +8 more
doaj   +1 more source

Inferring past demography and genetic adaptation in Spain using the GCAT cohort

Scientific Reports
Located in the southwestern corner of Europe, the Iberian Peninsula is separated from the rest of the continent by the Pyrenees Mountains and from Africa by the Strait of Gibraltar.
Jorge Garcia-Calleja, Simone A. Biagini, Rafael de Cid, Francesc Calafell, Elena Bosch   +4 more
doaj   +1 more source

Single-cell multi-omics dissection of RevitalAge Markers uncovers age-dependent immunotherapy resistance and druggable targets in melanoma

Biology Direct
Aging-related molecular reprogramming profoundly influences melanoma progression and therapeutic sensitivity, yet underlying mechanisms remain poorly understood.
Hanxiao Zhou, Benliang Wei, Wenlu Tan, Ji Shi, Changyuan Ren, Jinhao Zhang, Changlin Yang, Zheng Zhao, Shangwei Ning   +8 more
doaj   +1 more source