Results 71 to 80 of about 3,880 (180)

Regulation of dolichol-linked glycosylation [PDF]

, 2018
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNAc2Man9Glc3 on the polyprenol carrier dolichyl-pyrophosphate is compromised.
Welti, Michael
core  

Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture [PDF]

, 2013
Halloysite is aluminosilicate clay with a hollow tubular structure with nanoscale internal and external diameters. Assessment of halloysite biocompatibility has gained importance in view of its potential application in oral drug delivery.
Agarwal, Mangilal, Lai, Xianyin, Lvov, Yuri M., Pachpande, Chetan, Varahramyan, Kody, Witzmann, Frank A.   +5 more
core   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines

Molecular Oncology, 2022
Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three separately established breast EMT ...
Qiong Wang, Sigurdur Trausti Karvelsson, Freyr Johannsson, Arnar Ingi Vilhjalmsson, Lars Hagen, Davi deMiranda Fonseca, Animesh Sharma, Geir Slupphaug, Ottar Rolfsson   +8 more
doaj   +1 more source

Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease

Frontiers in Pharmacology, 2021
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in China. Sinisan (SNS) is a traditional Chinese medicine formula that has been widely used in treating chronic liver diseases, including NAFLD. However, its underlying
Xiaoyi Wei, Weixin Hou, Jiajun Liang, Peng Fang, Bo Dou, Zisong Wang, Jiayang Sai, Tian Xu, Chongyang Ma, Qiuyun Zhang, Fafeng Cheng, Xueqian Wang, Qingguo Wang   +12 more
doaj   +1 more source

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice [PDF]

, 2015
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Alessandro Vercelli, Barbara Ruozi, Carlos Cepeda, Claudio Caccia, Costanza Ferrari Bardile, Daniela Belletti, Elena Cattaneo, Eleonora Di Paolo, Elisa Brilli, Flavio Forni, Giovanni Tosi, HDCRG, Jane Y Chen, Maria A Vandelli, Marina M Boido, Marta Valenza, Marullo M, Michael S Levine, Paxinos G, Sethi A, Stefano Di Donato, Trager U, Valerio Leoni   +22 more
core   +4 more sources

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7 [PDF]

, 2007
BACKGROUND: Extracts from the rhizome of Cimicifuga racemosa (black cohosh) are increasingly popular as herbal alternative to hormone replacement therapy (HRT) for the alleviation of postmenopausal disorders. However, the molecular mode of action and the
Gaube, F., Pusch, L., Kroll, T., Woelfl, S., Hamburger, M.   +4 more
core   +1 more source

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell, Joshua A. Kulas, William E. Carter, June Javens‐Wolfe, Raven Dance Hinkel, Mustapha Moussaif, Jacob S. Smiley, Olivia Lazaro, Sylvia Robertson, Alan D. Palkowitz, Bruce T. Lamb, Timothy I. Richardson, Jeffrey L. Dage, Shaoyou Chu, Travis Johnson, Louis F. Stancato, Abdul Qadir Syed   +16 more
wiley   +1 more source

Correlation evaluation between cancer microenvironment related genes and prognosis based on intelligent medical internet of things

Frontiers in Genetics, 2023
The study of tumor microenvironment plays an important role in the treatment of cancer patients. In this paper, intelligent medical Internet of Things technology was used to analyze cancer tumor microenvironment-related genes.
Shoulei Ren, Wenli Cao, Jianzeng Ma, Hongchun Li, Yutao Xia, Jianwen Zhao   +5 more
doaj   +1 more source