Results 81 to 90 of about 3,880 (180)

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, Volume 4, Issue 1, Page 36-54, February 2026.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Vitamin D related genes in lung development and asthma pathogenesis [PDF]

, 2014
Background: Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma, suggesting that in utero changes related to vitamin D responsive genes might play a crucial role in later disease susceptibility.
Anderson, Chris, Gaedigk, Roger, Kho, Alvin T, Klanderman, Barbara, Leeder, James S, Niu, Simin, Qiu, Weiliang, Sharma, Sunita, Tantisira, Kelan G, Weiss, Scott T   +9 more
core   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

BMC Cancer, 2021
Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC).
Chao Yang, Shuoyang Huang, Fengyu Cao, Yongbin Zheng   +3 more
doaj   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains

Genetics Selection Evolution, 2012
Background Two atherosclerosis-susceptible and -resistant Japanese quail (Coturnix japonica) strains obtained by divergent selection are commonly used as models to study atherosclerosis, but no genetic characterization of their phenotypic differences has
Li Xinrui, Schulte Patricia, Godin David V, Cheng Kimberly M   +3 more
doaj   +1 more source

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]

, 2015
BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...
Chen, B.H., Courchesne P., Cupples L.A., Fox, C.S., Freedman J.E., Huan, T., Joehanes, R., Keles, S., Levy, D., Liu, C., Meigs J.B., Munson P.J., O'Donnell, C.J., Otlu, B., Tastan O., Yao, C., Zhang X.   +16 more
core   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

New aspects of cellular cholesterol regulation on blood glucose control- review and perspective on the impact of statin medications on metabolic health [PDF]

, 2017
Cholesterol is an essential component of cell membranes, and during the past several years, diabetes researchers have found that membrane cholesterol levels in adipocytes, skeletal muscle fibers and pancreatic beta cells influence insulin action and ...
Elmendorf, Jeffrey S., Grice, Brian A.
core   +1 more source

Engineering Gossypol‐Free Cottonseeds for Future Global Food Security and Agricultural Sustainability

Food Frontiers, Volume 7, Issue 1, January 2026.
This study depicting the role of transcriptomics, RNA interference (RNAi), and CRISPR/Cas9 technologies in the breeding of glandless cottonseed and glanded cotton tissues. This approach demonstrates the potential of cotton as a dual‐purpose crop, serving both the fiber industry and as a sustainable food and feed source.
Teame Gereziher Mehari, Muhammad Yousaf Shani, Junfeng Tang, Hui Fang, Muhammad Jawad Umer, Fang Liu, Kai Wang, Dengbing Yao, Muhammad K. R. Khan, Baohua Wang   +9 more
wiley   +1 more source