Results 101 to 110 of about 3,880 (180)

Survival of adult neurons lacking cholesterol synthesis in vivo

BMC Neuroscience, 2007
Background Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the ...
Möbius Wiebke, Xiao Le, Saher Gesine, Fünfschilling Ursula, Nave Klaus-Armin   +4 more
doaj   +1 more source

Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. [PDF]

, 2013
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current ...
Bosman, F., Budinska, E., D'Ario, G., Delorenzi, M., Di Narzo, A.F., Hodgson, J.G., Lapique, N., Popovici, V., Roth, A., Sikora, K.O., Tejpar, S., Weinrich, S., Yan, P.   +12 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival [PDF]

, 2008
Background We have engaged in an international program designated the Bank On A Cure, which has established DNA banks from multiple cooperative and institutional clinical trials, and a platform for examining the association of genetic variations with ...
Brian Van Ness, Christine Ramos, Majda Haznadar, Antje Hoering, Jeff Haessler, John Crowley, Susanna Jacobus, Martin Oken, Vincent Rajkumar, Philip Greipp, Bart Barlogie, Brian Durie, Michael Katz, Gowtham Atluri, Gang Fang, Rohit Gupta, Michael Steinbach, Vipin Kumar, Richard Mushlin, David Johnson, Gareth Morgan, ES Lander, JC Venter, International Human Genome Consortium, RA Kyle, PL Bergsagel, JD Shaughnessy, MW Jenner, WJ Chng, NE Kay, MM Oken, B Barlogie, PD Stenson, T Zhao, HJ Kang, RD Miller, KR Ahmadi, P Hardenbol, M Kearns, Valentin Dinu, Ian H Witten, Terry M Therneau, A Agreti, L Breiman, B Efron, EL Kaplan, MD Shriver, C Kawamura, IU Schraufstatter, N Yanamandra, M Bamshad, RK Dasgupta, C Zheng, JR Long, A Li, SW Kim, N Fukushima, Y Alvarado, L Hu, MA van der Pol   +59 more
core   +1 more source

Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension

Epigenetics
The complex pathophysiology of essential hypertension (EH) continues to pose challenges to blood control. This study investigated the association of blood DNA methylation and gene expression with EH in blood and arterial tissues to identify potential ...
Xinmeng Hu, Huizhen Jin, Xiaoyang Li, Zhuoshuai Liang, Jikang Shi, Hongrui Zhang, Jiahui Zhao, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu   +10 more
doaj   +1 more source

Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury [PDF]

, 2012
International audienceWe have analyzed transcriptomic, proteomic and metabolomic profiles of hepatoma cells cultivated inside a microfluidic biochip with or without acetaminophen (APAP). Without APAP, the results show an adaptive cellular response to the
Aninat, Caroline, Bois, Frédéric Y., Brochot, Céline, Bunescu, Andrei, Corlu, Anne, Dumas, Marc-Emmanuel, Elena-Herrmann, Bénédicte, Griscom, Laurent, Leclerc, Eric, Legallais, Cécile, Prot, Jean-Matthieu, Razan, Florence, Snouber, Leila Choucha   +12 more
core   +4 more sources

Integrative analysis of metabolomics and transcriptomics reveals alterations in egg quality and hepatic lipid metabolism in hens supplemented with curcumin

Animal Nutrition
Curcumin has been shown to affect lipid metabolism in various ways, but its molecular mechanisms in hens remain poorly understood. In this study, 378 Hy-Line Brown hens, aged 58 weeks, were randomly assigned into three groups, each consisting of 6 ...
Cunzhi Zou, Haiyu Jiang, Xuanfu Wu, Jiang Gao, Wenqiang Ma   +4 more
doaj   +1 more source

Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation [PDF]

, 2011
Pathway-based association methods have been proposed to be an effective approach in identifying disease genes, when single-marker association tests do not have sufficient power.
Kai eWang, Kai eWang, Andrew C Edmondson, Andrew C Edmondson, Mingyao eLi, Fan eGao, Atif N Qasim, Joseph M Devaney, Mary Susan eBurnett, Dawn M Waterworth, Vincent eMooser, Struan F.A. Grant, Struan F.A. Grant, Stephen E Epstein, Muredach P Reilly, Hakon eHakonarson, Hakon eHakonarson, Daniel J Rader, Daniel J Rader   +18 more
core   +1 more source

Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway

Cell Communication and Signaling
As a hydroxymethylglutaryl‒coenzyme A reductase (HMGCR) inhibitors, atorvastatin (ATST) has garnered widespread attention because of its antitumor effects. However, its specific mechanism of action remains incompletely understood.
Jiale Xu, Xiaoyu Qin, Longying Xiong, Cheng Zhao, Dan Ge, Yanping Wu, Yixuan Shen, Mengli Yang, Bihan Shen, Min Chen, Chen Min   +10 more
doaj   +1 more source

Integrated metabolomics and proteomics analysis reveals the accumulation mechanism of bioactive components in Polygonatum odoratum

Frontiers in Plant Science
Polygonatum odoratum (Mill.) Druce is rich in bioactive components with high medicinal value. To maximize the clinical benefits, it is of great significance to efficiently extract key bioactive components from appropriate growth stages in which they are ...
Shuang Liang, Yang Zhao, Zhaohui Luo, Junchen Liu, Xicen Jiang, Bingxian Yang, Lin Zhang, Hongwei Fu, Zhuoheng Zhong   +8 more
doaj   +1 more source