Results 21 to 30 of about 2,439 (113)

Farnesyl-diphosphate farnesyltransferase 1 promotes growth of colorectal cancer cells with dependence on tumor immune microenvironment

Di-san junyi daxue xuebao, 2021
Objective To investigate the effects of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) on the growth of colorectal cancer (CRC) cell line MC-38 in vitro and in mouse models of colorectal peritoneal metastasis and xenograft tumor.
LUO Na, LUO Na, ZHANG Dapeng, MIAO Hongming, DAI Rongyang   +4 more
doaj   +1 more source

Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis

Cancer Cell International, 2021
Background Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target
Ruiyang Zhao, Bo Cao, Hanghang Li, Tian Li, Xingming Xu, Hao Cui, Huan Deng, Bo Wei   +7 more
doaj   +1 more source

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility [PDF]

Oncogene
Yaohui Wang, Wenjin Yin, Liheng Zhou
exaly   +2 more sources

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

Cells, 2020
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Nguyen Thi Ha, Chang Hoon Lee
doaj   +1 more source

Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism [PDF]

PeerJ, 2023
Gypenosides (GP), extracted from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino, have been used to treat metabolic disorders, including lipid metabolism disorders and diabetes. Although recent studies have confirmed their beneficial
Tingting Zhou, Ligang Cao, Yimei Du, Lin Qin, Yanliu Lu, Qianru Zhang, Yuqi He, Daopeng Tan   +7 more
doaj   +2 more sources

Disrupted Lipid Metabolism Aggravates Ischemic Brain Injury: Targeting FDFT1 for Stroke Therapy [PDF]

Molecular Neurobiology
Yang Ting-Ting
exaly   +2 more sources

Retraction Note: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression [PDF]

Nature Communications
Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao   +15 more
doaj   +2 more sources

RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Nature Communications, 2020
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao   +15 more
doaj   +1 more source

Transcriptome analysis reveals the effect of grafting on gossypol biosynthesis and gland formation in cotton

BMC Plant Biology, 2023
Background Gossypol is a unique secondary metabolite and sesquiterpene in cotton, which is mainly synthesized in the root system of cotton and exhibits many biological activities.
Kun Ye, Teng Teng, Teng Yang, Degang Zhao, Yichen Zhao   +4 more
doaj   +1 more source

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

International Journal of Genomics, 2018
Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors.
Mehdi Dehghani, Zahra Samani, Hassan Abidi, Leila Manzouri, Reza Mahmoudi, Saeed Hosseini Teshnizi, Mohsen Nikseresht   +6 more
doaj   +1 more source