Results 11 to 20 of about 2,439 (113)

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer [PDF]

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, as chemotherapy resistance leads to relapse in many patients. Carboplatin addition improves treatment response, but challenges persist.
Yuexiang Zeng, Zhijie Xu, Juan Huang, Qiaoli Yi, Xi Chen, Jiayu Wang, Zhihao Du, Jian Tian, Yuanliang Yan   +8 more
doaj   +2 more sources

Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway [PDF]

Cell Communication and Signaling
As a hydroxymethylglutaryl‒coenzyme A reductase (HMGCR) inhibitors, atorvastatin (ATST) has garnered widespread attention because of its antitumor effects. However, its specific mechanism of action remains incompletely understood.
Jiale Xu, Xiaoyu Qin, Longying Xiong, Cheng Zhao, Dan Ge, Yanping Wu, Yixuan Shen, Mengli Yang, Bihan Shen, Min Chen, Chen Min   +10 more
doaj   +2 more sources

Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis [PDF]

Stem Cell Research & Therapy
Background Stem cell therapies have emerged as transformative therapeutic strategies for neurological disorders. However, neurons derived from transplanted stem cells often exhibit low survival rates and remain in an immature state.
Ping Chen, Jingyi Li, Vsevolod Telezhkin, Yu Gu, Min Tao, Liping Guo, Simin Song, Rihe Dong, Xianyang Luo, Yan Wang, Qian Liu, Weiming Tian, Weihua Meng, Wei Hong, Bing Song   +14 more
doaj   +2 more sources

Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors [PDF]

iScience
Summary: Subterranean burrows of plateau zokors (Eospalax baileyi) on the Qinghai-Tibet Plateau become significantly colder and more hypoxic with increasing altitude.
Qingfei Hu, Linna Wei, Zhifang An, Yaxuan Wang, Tongzuo Zhang, Dengbang Wei   +5 more
doaj   +2 more sources

Integrated Multi-Omics Investigation of Gypenosides’ Mechanisms in Lowering Hepatic Cholesterol [PDF]

Biomolecules
(1) Objective: This study aimed to systematically elucidate the molecular mechanisms by which gypenosides (GP), a major active component of Gynostemma pentaphyllum, ameliorate hypercholesterolemia by modulating the hepatic steroidogenesis pathway, and to
Qin Jiang, Tao Yang, Hao Yang, Yi Chen, Yuan Xiong, Lin Qin, Qianru Zhang, Daopeng Tan, Xingdong Wu, Yongxia Zhao, Jian Xie, Yuqi He   +11 more
doaj   +2 more sources

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells [PDF]

iScience
Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li   +7 more
doaj   +2 more sources

Intestinal microbiota-host crosstalk reveals mechanisms regulating residual feed intake in egg-type ducks [PDF]

BMC Genomics
Background As an important economic trait in ducks, residual feed intake (RFI) may be influenced by the intestinal microbiota. However, the mechanisms underlying microbiota-host crosstalk remain unclear.
Zhiyu He, Xuli Chi, Shiying Ruan, Rulong Lin, Hongping Chen, Kaixian Cai, Xiaolong Ye, Jiwei Hu, Hua He, Liang Li, Hehe Liu, Jiwen Wang   +11 more
doaj   +2 more sources

Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning [PDF]

Journal of Hepatocellular Carcinoma
Qiqi Liu,1 Yinuo Yang,1 Yongshuai Wang,2 Shuhang Wei,1 Liu Yang,1 Tiantian Liu,1 Zhen Yu,3 Yuemin Feng,3 Ping Yao,4 Qiang Zhu1,5 1Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan ...
Liu Q, Yang Y, Wang Y, Wei S, Yang L, Liu T, Yu Z, Feng Y, Yao P, Zhu Q   +9 more
doaj   +2 more sources

Population-based genome-wide association study of plasma complex lipid species [PDF]

Nature Communications
The human lipidome comprises numerous complex lipids, dysregulation of which can contribute to the pathogenesis of a wide range of diseases. Despite the high heritability of parts of the lipidome, the genetic architecture of many circulating lipid ...
Elvire N. Landstra, Mohammed A. Imtiaz, Valentina Talevi, Fabian Eichelmann, Matthias B. Schulze, N. Ahmad Aziz, Monique M. B. Breteler   +6 more
doaj   +2 more sources

Dual Regulatory Mechanisms of Expression and Mutation Involving Metabolism-Related Genes FDFT1 and UQCR5 during CLM

Molecular Therapy - Oncolytics, 2019
Colorectal cancer (CRC) is the third most common cancer worldwide, and liver metastasis presents a major cause of CRC-associated death. Extensive genomic analysis has provided valuable insight into the pathogenesis and progression of CRC; however, a ...
Da Fu, Tao Huang, Lin-Lin Tian
exaly   +3 more sources