Results 141 to 150 of about 53,667,156 (250)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

CART machine learning peeling pathways for anxiety and depression severity classification in population screening. [PDF]

Glob Epidemiol
Faro A, Tejada J, Al-Delaimy WK.
europepmc   +1 more source

Sonhar em Faro

, 2003
Proposta para que, com a criação do Estádio do Algarve e do Hospital Central do Algarve, ambos no Parque das Cidades Loulé / Faro, se dê como destino ao Estádio de São Luís e ao Hospital de Faro a implosão de ambos, criando uma zona verde, um parque ...
Pereira, Renato
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Halibee member archaeology: Middle Stone Age environment, technology, and postmortem modifications. [PDF]

Proc Natl Acad Sci U S A
Beyene Y, Asfaw B, White TD, WoldeGabriel G, Bernor R, Bibi F, Boisserie JR, Brasil MF, Brochu CA, Carlson JP, García NG, Giaourtsakis IX, Hailu H, Hart WK, Head JJ, Hlusko LJ, Kaya F, Louchart A, Melaku S, Müller J, Niespolo EM, Pehlevan C, Renne PR, Souron A, Sánchez-Romero L.   +24 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

MRI metal artifact characterization in patients with spinal cord injury at 3 Tesla. [PDF]

Spinal Cord
Mohamed FB, Middleton DM, Manmatharayan A, Harrop JS, Kreidie F, Fisher J, Alizadeh M, Talekar K, Karambelkar A, Faro SH, Flanders AE, Krisa L.   +11 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Trophic and Microbial Dynamics in a Mediterranean Transitional Ecosystem (Lake Faro, Southern Italy): Implications for <i>Pinna nobilis</i> Conservation. [PDF]

Microorganisms
Caruso G, Giacobbe S, Azzaro F, Decembrini F, Leonardi M, Maimone G, Profeta A, Rinelli P.   +7 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source