Leveraging Viscosity to Unlock the Osteogenic Potential of BMP‐2 Mimetic DWIVA
Small, EarlyView.Dynamic interfaces based on supported lipid bilayers demonstrate that the osteogenic potential of the BMP‐2 mimetic DWIVA can be harnessed by modulating substrate viscosity. This work highlights that the viscous properties of the cellular microenvironment play a crucial role in the mechanosensitive regulation of growth factor activity.
Finlay Cunniffe +5 more
wiley +1 more source
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. [PDF]
Elife, 2021 Jeong D +15 more
europepmc +1 more source
Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side
Allergy, EarlyView.ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm +9 more
wiley +1 more source
The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region. [PDF]
PLoS One, 2021 Kajikawa O +4 more
europepmc +1 more source
Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism [PDF]
, 1996 N S Williams, Víctor H. Engelhard
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich +7 more
wiley +1 more source
Fas-Fas Ligand Interactions Are Essential for the Binding to and Killing of Activated Macrophages by γδ T Cells [PDF]
, 2004 Jane E. Dalton +4 more
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Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells
Cancer Science, EarlyView.Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao +12 more
wiley +1 more source
Serum Levels of Soluble Fas and Fas Ligand in Iranian Women with Pre-eclampsia. [PDF]
Rep Biochem Mol Biol, 2021 Masoumi E +5 more
europepmc +1 more source
Cancer Science, EarlyView.Ramucirumab (RAM) plus docetaxel (DOC) after PD‐1 inhibitors showed clinical activity, with responders exhibiting maintained anti–PD‐1 (IgG4+)‐bound CD8+ T cells and decreased IgG4+ Tregs. A sequential strategy of administering RAM plus DOC during persistent anti–PD‐1 antibody binding may be beneficial in patients with advanced non‐small cell lung ...
Kinnosuke Matsumoto +20 more
wiley +1 more source