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Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice. [PDF]
Cell Death Discov, 2019 Trivedi PM +8 more
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Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. [PDF]
J Immunol, 2018 Kotov DI +3 more
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Targeting the Fas/Fas ligand pathway in cancer
Expert Opinion on Therapeutic Targets, 2005Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas ligand (FasL). Although originally described as an important regulator of peripheral immune homeostasis, accumulating evidence suggests that the Fas/FasL system plays an important role in tumour development.
Kenneth Nally +2 more
exaly +3 more sources
Expression of Fas and Fas Ligand in Hodgkin's Disease
Leukemia and Lymphoma, 1999Fas and Fas ligand expression were investigated in twenty two cases of classical Hodgkin's disease (HD) by immunohistochemistry. While Reed-Sternberg (RS) cells in 7/22 (32%) cases expressed Fas ligand, reactive lymphoid cells expressed Fas ligand in only 2 (9%) cases. In 20/22 (91%) cases, the RS cells expressed Fas. A higher proportion of RS cells in
Suresh H Advani, J J Nadkarni
exaly +3 more sources
Involvement of Fas-Fas Ligand Interactions in Graft Rejection
International Reviews of Immunology, 1999The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that these tissues may be targets of ...
Olivia M Martinez +2 more
exaly +3 more sources
Fas, Fas ligand,and transfusion immunomodulation
Transfusion, 2001dem-onstrated that soluble HLA class I (sHLA-I) moleculesupregulate FasL expression and sFasL secretion in activatedFas-positive CD8+ T-cells and trigger their apoptosis. Thelevel of sHLA-I molecules is significantly increased in theserum of patients with an activation of their immune sys-tem, such as occurs during acute rejection of organ al-lografts,
PUPPO, FRANCESCO +4 more
openaire +3 more sources
Structure and Function of Fas/Fas Ligand
International Reviews of Immunology, 1999Fas is a member of the TNF receptor family, that contain 2-6 cysteine-rich domains (CRDs) in their extracellular regions, a single transmembrane domain and variably sized intracytoplasmic domains. Fas belongs to a subgroup of family members that have a "death domain" near the carboxy-terminal region of the molecule.
J R, Orlinick, A K, Vaishnaw, K B, Elkon
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Expression of Fas‐Fas Ligand in Murine Testis
American Journal of Reproductive Immunology, 1999Xu JP, Li X, Mori E, Guo MW, Matsuda I, Takaichi H, Amano T, Mori T. Expression of Fas‐Fas ligand in murine testis. AJRI 1999; 42:381–388 © Munksgaard, CopenhagenPROBLEM: During spermatogenesis, it has been suggested that the number of germ cells to be matured is regulated and restricted through the apoptotic mechanism.
J P, Xu +7 more
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Fas/Fas ligand and hematopoietic progenitor cells
Current Opinion in Hematology, 1998Fas antigen is a receptor that crosslinks with a ligand or antibody initiating a signal transduction cascade that leads to apoptosis. During normal hematopoiesis, Fas antigen is not expressed on CD34+ cells, including premature hematopoietic progenitor cells. Functioning Fas antigen expression is induced by several hematopoietic regulators.
Y, Niho, Y, Asano
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