Results 171 to 180 of about 59,326 (211)

Fas and Fas ligand: lpr and gld mutations

Immunology Today, 1995
Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and FasL, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the ...
S, Nagata, T, Suda
openaire   +2 more sources

Fas and Fas Ligand Expression in Pancreatic Adenocarcinoma

Pancreas, 2002
Fas and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance, and expression of FasL by tumors may mediate their counterattack on cytotoxic lymphocytes. Both proteins are expressed in most if not all pancreatic carcinoma cell lines, but their study in primary human tumors has been limited.We performed Fas and FasL ...
Nat L, Pernick, Fazlul H, Sarkar, Pam, Tabaczka, Glenn, Kotcher, John, Frank, N Volkan, Adsay   +5 more
openaire   +2 more sources

Immunolocalization of FAS and FAS ligand in inflammatory myopathies

Acta Neuropathologica, 2001
Fas/Fas ligand (FasL) interaction can induce apoptosis, have a costimulatory role or act as a mechanism by which cytotoxic T cells produce target cell lysis. We used several commercially available antibodies to study Fas and FasL expression in polymyositis (PM), inclusion body myositis (IBM), dermatomyositis (DM) and normal controls.
J L, De Bleecker, V I, Meire, I E, Van Walleghem, I M, Groessens, J M, Schröder   +4 more
openaire   +2 more sources

Fas and Fas‐ligand expression in seminomatous testes

APMIS, 1999
Sixteen seminomas with surrounding tissue containing normal and precancerous (cis) seminiferous tubules were examined for the expression of Fas (CD95, APO‐1) and Fas ligand (FasL) (CD95L). This was done by analyzing frozen specimens using immunohistochemistry with antibodies directed against Fas and FasL.
O, Braendstrup, B, Bols, L, Jensen
openaire   +2 more sources

Soluble Fas and Fas Ligand in Pregnancy

Angiology, 2011
The pathophysiology of pregnancy-induced hypertension and preeclampsia may involve abnormalities in placentation and the Fas/Fas ligand system. Hypothesizing abnormal plasma Fas and Fas ligand in pregnancy-induced hypertension, we recruited 20 hypertensive pregnant women at mean week 15 and 29 at week 30: 18 were studied at both time points.
Velore J, Karthikeyan, Gregory Y H, Lip, Sabah, Baghdadi, Deirdre A, Lane, D Gareth, Beevers, Andrew D, Blann   +5 more
openaire   +2 more sources

Fas and Fas ligand expression in Alzheimer's disease

Acta Neuropathologica, 2001
The Fas/Fas ligand (L) signaling system has been implicated in the control of cell death and cell survival of T and B lymphocytes and in a variety of cell types under particular pathological conditions. In the present study we examined the expression of Fas and Fas-L, by Western blotting and immunohistochemistry, in the human frontal cortex and ...
I, Ferrer, B, Puig, J, Krupinsk, M, Carmona, R, Blanco   +4 more
openaire   +2 more sources

Fas ligand: receptor or ligand?

Apoptosis, 1999
In this review, we chronicle the discovery, biochemical characterization, and assignment of Fas (CD95) as receptor and Fas Ligand (FasL, CD95L) as ligand. We review the functional descriptions of the molecules as death-inducing receptor and ligand or as mediators of cell division and/or growth arrest.
M K, Newell, J, Desbarats
openaire   +2 more sources

Fas ligand in human serum

Nature Medicine, 1996
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas-bearing cells. The membrane-bound human FasL was found to be converted to a soluble form (sFasL) by the action of a matrix metalloproteinase-like enzyme. Two neutralizing monoclonal anti-human FasL antibodies were identified, and an enzyme-linked immunosorbent
M, Tanaka, T, Suda, K, Haze, N, Nakamura, K, Sato, F, Kimura, K, Motoyoshi, M, Mizuki, S, Tagawa, S, Ohga, K, Hatake, A H, Drummond, S, Nagata   +12 more
openaire   +2 more sources

Polymorphisms of FAS and FAS ligand genes in preeclamptic women

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010
This study investigated the influence that Fas and Fas ligand gene polymorphisms might have on preeclampsia. The pathogenesis of preeclampsia is still enigmatic and several studies have proposed that it may, in part, be determined by genetic susceptibility.
Ciarmela, Pasquapina, Boschi, Sonia, Bloise, Enrrico, Marozio, Luca, Benedetto, Chiara, Castellucci, Mario, Petraglia, Felice   +6 more
openaire   +4 more sources

Downregulation of Fas ligand by shedding

Nature Medicine, 1998
Apoptosis-inducing Fas ligand (FasL) is a type II membrane protein, predominantly expressed in the activated T cells. FasL is cleaved by a putative metalloproteinase to produce a soluble form. Here, we blocked the shedding of human FasL by deleting its cleavage site.
M, Tanaka, T, Itai, M, Adachi, S, Nagata
openaire   +2 more sources