Results 241 to 250 of about 287,562 (282)

Zearalenone induces apoptosis of rat Sertoli cells through Fas‐Fas ligand and mitochondrial pathway

Environmental Toxicology, 2019
Zearalenone (ZEA) is an estrogen‐like toxin produced by Fusarium that is widely found in cereals worldwide. In recent years, ZEA has been found to cause reproductive dysfunction in male animals, but the underlying mechanism remains unclear.
G. Cai, Mengxue Si, Xi Li, H. Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bian   +8 more
semanticscholar   +1 more source

Apoptosis-related proteins (Fas, Fas ligand, bcl-2 and p53) in different types of human breast tumors

Oncology Reports, 2002
The aim of this study was to evaluate the possible role of apoptosis-related proteins (ARP: Fas and Fas ligand, bcl-2, p53) in the progress of tumorigenesis in breast cancer. Epithelial tumor cells and lymphocytes were analyzed immunohistochemically for the rate of lymphoid infiltration and presence of ARP in 50 human breast tumors of different types ...
Herzl, Ben-Hur, Eitan, Mordechay, Reuvit, Halperin, Pavel, Gurevich, Judit, Zandbank, Meherdad, Herper, Itshak, Zusman   +6 more
openaire   +2 more sources

The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells

Biochemical and Biophysical Research Communications, 2008
Fas Ligand (FasL, CD178) is a cytokine that may be secreted or expressed as a transmembrane ligand at the cell surface, and induces apoptosis by binding to the "death receptor" Fas (CD95). Here, we show that Grb2, an SH3 domain-containing adaptor protein, binds to the proline-rich domain of FasL and regulates its cell surface expression.
Peter B, Thornhill, Jason B, Cohn, William L, Stanford, Julie, Desbarats   +3 more
openaire   +2 more sources

Sensitization of immunoresistant prostate carcinoma cell lines to Fas/Fas ligand‐mediated killing by cytotoxic lymphocytes: Independence of de novo protein synthesis

The Prostate, 1999
We recently reported that drug-resistant prostate tumor cells (DU145, PC-3) are resistant to Fas-mediated killing by cytotoxic lymphocytes, and that this resistance can be overcome by treatment with subtoxic concentrations of chemotherapeutic drugs. Fas belongs to the tumor necrosis factor (TNF) family of receptors.
P. Frost, A. Belldegrun, B. Bonavida
semanticscholar   +3 more sources

Protein Expression of Fas, Fas Ligand, Bcl-2 and TGFβ2 and Correlation with Survival in Initial and Recurrent Human Gliomas

Journal of Neuro-Oncology, 2004
Several studies have recently demonstrated that human gliomas express Fas, Fas ligand (FasL), Bcl-2 and TGFbeta2 at some degree. These factors are considered to interact with apoptotic processes and to have immuno-reactive potential. Their role for tumor evasion from the immune surveillance is currently under examination. To date, there is only limited
Rainer J, Strege, Christian, Godt, Andreas M, Stark, Heinz-Hermann, Hugo, H Maximilian, Mehdorn   +4 more
openaire   +2 more sources

Erhöhte Expression der Apoptose induzierenden Proteine Fas Antigen und Fas Ligand auf mononukleären Zellen septischer Patienten

1997
Wahrend der Sepsis kommt es zu einer Hemmung des zellularen und humoralen Immunsystems durch eine massive Lymphozytopenie und Funktionseinschrankung mononuklearer Zellen [1, 2]. Der programmierte Zelltod (Apoptose) spielt fur die zellulare Homoostase eine wichtige Rolle.
U. Ungethüm, M. Keel, O. Trentz, W. Ertel   +3 more
openaire   +1 more source

Altered protein expression levels of Fas/CD95 and Fas Ligand in differentially vulnerable brain areas in rats after global cerebral ischemia

Neuroscience Letters, 2003
To assess the role of the apoptosis-inducing death receptor Fas/CD95 and Fas Ligand (FasL) after global cerebral ischemia, expression of these proteins was investigated in differentially, i.e. selectively vulnerable brain areas. Following experimentally induced cardiac arrest of 6 min duration, rats were resuscitated.
S A, Padosch, E, Popp, P, Vogel, B W, Böttiger   +3 more
openaire   +2 more sources

Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein

Virus Research, 2003
Tumour cells and virus infected cells expressing Fas ligand (FasL) can evade immune surveillance by inducing apoptosis in T cells expressing Fas. In order to characterise a possible role of hepatitis C virus (HCV) core protein in similar mechanisms during HCV infection, we investigated Fas ligand expression and activity in a human hepatoblastoma cell ...
A, Ruggieri, M, Murdolo, M, Rapicetta
openaire   +2 more sources

[Expression of Fas, Fas ligand, Fas-associated death domain protein, caspase 8 and mutant P53 protein in esophageal squamous cell carcinoma].

Zhonghua yi xue za zhi, 2008
To investigate the expression of five apoptosis-related proteins, Fas, Fas ligand (FasL), Fas-associated death domain protein (FADD), caspase 8, and mutant p53, in human esophageal squamous cell carcinoma (ESCC) tissue, and analyze the association of these proteins with ESCC malignant progression.116 ESCC specimens obtained during operation.
Li-yan, Xue, Li-qun, Ren, Wei, Luo, Xiang-jun, Guan, Shuang-mei, Zou, Shan, Zheng, Rui, Bi, Yong-qiang, Xie, Zu-gen, He, Ning, Lü   +9 more
openaire   +1 more source

Effects of melittin on expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas Ligand in hepatocarcinoma cells

Journal of Chinese Integrative Medicine, 2007
To observe the effects of melittin on the expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas ligand (FasL) in hepatocarcinoma cells in vitro and to study the mechanisms of melittin in inducing apoptosis of hepatocarcinoma cells.BEL-7402 cell line was treated with melittin in vitro.
Chen, Zhang, Bai, Li, Shu-qin, Lu, Yong, Li, Yong-hua, Su, Chang-quan, Ling   +5 more
openaire   +2 more sources