Results 171 to 180 of about 1,659,663 (259)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Fashion in the Nineties Symposium: Patricia Mears, "Spectacle: Fashion on Parade"

open access: yes
MFIT Deputy Director Patricia Mears reviews the many groundbreaking runway shows from the 1990s for The Museum at FIT's 26th academic symposium “Reinvention and Restlessness: Fashion in the Nineties” on February 11, 2022.

core  

David-V Procedure Combined with Zone 2 Arch Replacement for Acute Stanford Type A Dissection. [PDF]

open access: yesMethodist Debakey Cardiovasc J
Gecse I   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

2010 FIT Fashion Show part 4: Children's Wear

open access: yes
Children's Wear designed by graduating students in FIT's BFA fashion design program.

core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

100 Years of Fashion: Part Two

open access: yes
The Museum at FIT is excited to present 100 Years of Fashion, a two-part introduction to the history of fashion from the late 19th century through the 1990s. These two videos were originally created for high school students enrolled in FIT's Summer Live,

core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

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