Results 181 to 190 of about 35,096 (229)
Cell Death and Differentiation, 2007 The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity.
Thorsten Maretzky +2 more
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Journal of Leukocyte Biology, 2021
AbstractFas ligand (FasL) is best known for its ability to induce cell death in a wide range of Fas-expressing targets and to limit inflammation in immunoprivileged sites such as the eye. In addition, the ability of FasL to induce a much more extensive list of outcomes is being increasingly explored and accepted. These outcomes include the induction of
Meredith, Gregory-Ksander +1 more
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AbstractFas ligand (FasL) is best known for its ability to induce cell death in a wide range of Fas-expressing targets and to limit inflammation in immunoprivileged sites such as the eye. In addition, the ability of FasL to induce a much more extensive list of outcomes is being increasingly explored and accepted. These outcomes include the induction of
Meredith, Gregory-Ksander +1 more
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FasL shedding is reduced by hypothermia in experimental stroke [PDF]
Journal of Neurochemistry, 2008 Protection by mild hypothermia has previously been associated with better mitochondrial preservation and suppression of the intrinsic apoptotic pathway.
Jong Youl Kim +2 more
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RGD-FasL Induces Apoptosis of Pituitary Adenoma Cells
Cellular and Molecular Immunology, 2008 This study was to investigate the cytotoxic effects on pituitary adenoma cell lines GH3/MMQ/AtT20 induced by RGD-FasL and the underlying mechanism. Fas/DcR3 mRNAs were detected by RT-PCR and their surface expressions were measured by flow cytometry ...
Lukui Chen, Guohong Zhuang, Wenzhu Li
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FasL Expression and Reverse Signalling
2009FasL plays a central role in the induction of apoptosis within the immune system. It mediates activation-induced cell death (AICD) of T lymphocytes and contributes to the cytotoxic effector function of T and NK cells. Moreover, FasL is discussed as direct effector molecule for the establishment of immune privilege and tumour survival. Besides its death-
M, Lettau +3 more
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2007
The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule.
Anja Krippner-Heidenreich +1 more
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The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule.
Anja Krippner-Heidenreich +1 more
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Cellular Signalling, 2006
As a death factor of T cells and Natural Killer (NK) cells, Fas Ligand (FasL) is stored in association with secretory lysosomes. Upon stimulation, these cytotoxic granules are transported to the cell membrane where FasL is exposed on the cell surface, shed or secreted.
Jing, Qian +6 more
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As a death factor of T cells and Natural Killer (NK) cells, Fas Ligand (FasL) is stored in association with secretory lysosomes. Upon stimulation, these cytotoxic granules are transported to the cell membrane where FasL is exposed on the cell surface, shed or secreted.
Jing, Qian +6 more
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LKLF and FasL Expression: Correction and Clarification
Science, 1997In the report “LKLF: A transcriptional regulator of single-positive T cell quiescence and survival” ([26 Sept., p. 1986][1]) ([1][2]), we found increased Fas ligand (FasL) expression on lung Kruppel-like factor (LKLF)–deficient T cells.
C T, Kuo, M L, Veselits, J M, Leiden
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Experimental Cell Research, 2014
Fas ligand (FasL) is a death factor of the tumor necrosis factor superfamily. Like other members of this family of type II transmembrane proteins, FasL is subject to ectodomain shedding by a disintegrin and metalloproteinases (ADAMs) liberating soluble FasL and leaving membrane-integral N-terminal fragments (NTFs).
Marcus, Lettau +4 more
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Fas ligand (FasL) is a death factor of the tumor necrosis factor superfamily. Like other members of this family of type II transmembrane proteins, FasL is subject to ectodomain shedding by a disintegrin and metalloproteinases (ADAMs) liberating soluble FasL and leaving membrane-integral N-terminal fragments (NTFs).
Marcus, Lettau +4 more
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The Role of FasL and Fas in Health and Disease
2009The FS7-associated cell surface antigen (Fas, also named CD95, APO-1 or TNFRSF6) attracted considerable interest in the field of apoptosis research since its discovery in 1989. The groups of Shin Yonehara and Peter Krammer were the first reporting extensive apoptotic cell death induction upon treating cells with Fas-specific monoclonal antibodies.1,2 ...
Martin, Ehrenschwender, Harald, Wajant
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